123例節(jié)段型白癜風(fēng)的臨床特點(diǎn)分析
本文關(guān)鍵詞:123例節(jié)段型白癜風(fēng)的臨床特點(diǎn)分析 出處:《吉林大學(xué)》2017年碩士論文 論文類型:學(xué)位論文
更多相關(guān)文章: 節(jié)段型白癜風(fēng) 自身免疫性疾病 家族史
【摘要】:背景白癜風(fēng)在臨床上比較常見,是一種獲得性、持久性的皮膚粘膜色素脫失性疾病,世界范圍內(nèi)的人群發(fā)病率約為0.5%~1%。其發(fā)病與地域、性別無關(guān),任何年齡均可患病,但大多數(shù)患者在青少年期發(fā)病。根據(jù)2012年白癜風(fēng)全球問題共識(shí)大會(huì)(The Vitiligo Global Issues Consensus Conference,VGICC)及專家討論,目前主要將白癜風(fēng)分為四種類型:即節(jié)段型、非節(jié)段型、混合型以及未定型(原稱局限型)。其中非節(jié)段型包括散發(fā)型、泛發(fā)型、粘膜型以及面肢端型。在臨床工作中,常將非節(jié)段型、混合型、未定型統(tǒng)一歸為尋常型。目前,國內(nèi)關(guān)于節(jié)段型白癜風(fēng)的臨床特點(diǎn)方面的研究較少。目的收集白癜風(fēng)患者的臨床資料,分析節(jié)段型和尋常型白癜風(fēng)患者的臨床特點(diǎn)的差異,以此了解節(jié)段型白癜風(fēng)的臨床特征。材料與方法使用統(tǒng)一標(biāo)準(zhǔn)的白癜風(fēng)調(diào)查表,收集自2014年10月1日至2015年9月30日期間就診于我院皮膚科門診的白癜風(fēng)患者的臨床和流行病學(xué)資料。入選標(biāo)準(zhǔn):1所有患者均由副主任醫(yī)師及以上的專家確診,并已排除其他色素減退性疾病;2臨床診斷標(biāo)準(zhǔn)則參考趙辨主編的《臨床皮膚病學(xué)》中的關(guān)于白癜風(fēng)的診斷標(biāo)準(zhǔn);3患者的地域、種族、性別、年齡不限。排除資料記錄不完整的患者。收集合格的白癜風(fēng)患者的臨床資料共計(jì)1015例,其中節(jié)段型患者123例,尋常型患者892例(包括非節(jié)段型724例,混合型28例,未定型140例)。將收集并整理完成后的資料輸入社會(huì)科學(xué)統(tǒng)計(jì)軟件包SPSS20.0進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果1.節(jié)段型白癜風(fēng)患者共計(jì)123例,占同期全部患者的12.1%。其中男性59例,女性64例,男女發(fā)病比例0.92:1。節(jié)段型白癜風(fēng)患者的平均發(fā)病年齡為16.30±11.59歲,尋常型白癜風(fēng)患者平均發(fā)病年齡為22.24±14.80歲,兩者比較差異有統(tǒng)計(jì)學(xué)意義(t=5.128,P0.01)。在20歲之前發(fā)病的節(jié)段型患者共計(jì)86例,占69.9%。臨床最常見的發(fā)病部位為面頸部,其次為軀干。2.在發(fā)病年齡、發(fā)病部位、皮損面積、發(fā)病季節(jié)、伴發(fā)疾病、白癜風(fēng)家族史等方面,男女節(jié)段型患者的比較均無統(tǒng)計(jì)學(xué)差異。3.單節(jié)段型白癜風(fēng)最常見,共113例,占91.9%。皮損累及身體左右側(cè)無統(tǒng)計(jì)學(xué)差異。4.伴有自身免疫性疾病的節(jié)段型患者的平均發(fā)病年齡(25.11±13.27)大于不伴有自身免疫性疾病的患者的平均發(fā)病年齡(15.17±10.79),兩者比較差異有統(tǒng)計(jì)學(xué)意義(t=3.226,P=0.009)。5.12例(9.8%)節(jié)段型白癜風(fēng)患者有陽性家族史,有家族史的患者平均發(fā)病年齡(13.60±10.18)較無家族史的患者平均發(fā)病年齡(16.60±11.74)早,但差異(t=0.953,P=0.357)無統(tǒng)計(jì)學(xué)意義。有家族史的節(jié)段型患者在發(fā)病部位、發(fā)病季節(jié)、皮損面積等方面與無家族史的患者相比,無明顯差異。6.與尋常型白癜風(fēng)進(jìn)行比較,節(jié)段型白癜風(fēng)的陽性家族史少,伴發(fā)暈痣、白發(fā)癥及其他自身免疫性疾病的情況均少見(P0.05)。結(jié)論1.男女節(jié)段型白癜風(fēng)患者的臨床特點(diǎn)無顯著差異;2.單節(jié)段型白癜風(fēng)最常見,皮損累及身體左右側(cè)無差異;3.與尋常型白癜風(fēng)相比較,節(jié)段型白癜風(fēng)的發(fā)病年齡更早,陽性家族史少,伴發(fā)暈痣、白發(fā)癥及自身免疫性疾病少。
[Abstract]:Background vitiligo is more common in clinic, is an acquired, persistent skin depigmentation disease, the worldwide incidence rate is about 0.5%~1%. and the incidence of the region, regardless of gender, the prevalence of any age, but most patients in juvenile onset. According to the 2012 global consensus conference (The vitiligo Vitiligo Global Issues Consensus Conference, VGICC) and experts to discuss, at present mainly classified four types: segmental and non segmental type, mixed type and undifferentiated (formerly known as localized). The non segmental type including sporadic, pan hair, face and mucosal acral. In clinical work, often non segmental type, mixed type, unshaped unified into ordinary type. At present, there is less research on the clinical features of segmental vitiligo. The clinical data collection of vitiligo patients, divided Patients with vitiligo vulgaris and segmental analysis of the clinical characteristics of the differences, in order to understand the clinical features of segmental vitiligo. Materials and methods use standard of vitiligo questionnaire, collected from October 1, 2014 to September 30, 2015 in the Department of dermatology in our hospital vitiligo patients with clinical and epidemiological data of all patients. Inclusion criteria: 1 the deputy director of physicians and more experts diagnosed and excluded other hypopigmented diseases; 2 clinical diagnosis standard reference Zhao Bian, "clinical dermatology > about vitiligo diagnostic criteria; 3 patients in the region, race, gender, age is not restricted. Records of patients with incomplete exclusion clinical data were collected. The qualified vitiligo patients a total of 1015 cases, including 123 cases of patients with segmental, 892 cases of patients with vulgaris (including non segmental type in 724 cases, 28 cases of mixed type, and 140 undefined To collect and collate cases). After the completion of the data into the statistical package for social science SPSS20.0 for statistical analysis. Results 1. of segmental vitiligo patients were 123 cases, accounted for 12.1%. of all patients 59 cases were male, 64 were female, the average age of onset of male and female incidence ratio of 0.92:1. segmental type vitiligo patients was 16.30 + 11.59 years old, the average age of onset of vitiligo was 22.24 + 14.80, there was significant difference between the two groups (t=5.128, P0.01). Patients with segmental onset before the age of 20, a total of 86 cases, accounting for the most common site for clinical 69.9%. neck, followed by trunk.2. in age of onset. Location and lesion area, seasonal incidence, associated diseases, family history of vitiligo, and segmental patients were no significant differences of.3. single segment the most common type of vitiligo, a total of 113 cases, accounting for 91.9%. lesions involving the body No significant difference between the left and right side.4. associated with autoimmune diseases the average age of the patients with segmental (25.11 + 13.27) than the average age of onset was not associated with autoimmune disease patients (15.17 + 10.79), the difference was statistically significant (t=3.226 P= 0.009).5.12 (9.8%) cases of patients with segmental type of vitiligo have a positive family history, the average age of patients with family history (13.60 + 10.18) than the average age of patients without family history (16.60 + 11.74) early, but the difference (t=0.953, P=0.357). There is no significant seasonal segment with a family history of the disease, in the pathogenesis of the site, the lesion area as compared with patients with no family history, no significant difference between.6. and vitiligo vulgaris were compared, segmental vitiligo positive family history, halo nevi, white hair disease and other autoimmune diseases are rare (P0.05). Conclusion: 1. No significant differences in clinical characteristics of vitiligo patients and 2. segments; the most common single segmental vitiligo, no difference between the involvement of left and right side body; 3. with vitiligo vulgaris compared to earlier age of onset of segmental vitiligo, positive family history, halo nevi, white hair disease and autoimmune diseases less.
【學(xué)位授予單位】:吉林大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2017
【分類號(hào)】:R758.41
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