本文選題：近紅外 + 熒光染料�。� 參考：《華東理工大學》2017年碩士論文

【摘要】：熒光染料在生物醫(yī)學領(lǐng)域有著廣泛的應(yīng)用,如檢測、標記、光動力治療、光熱消融治療等。近紅外光的波長比普通可見光波長更長,其瑞利散射效應(yīng)更小,具有更好的組織穿透性;此外近紅外光的光毒性低,光熱性好,受到生物組織背景信號干擾小,650-900 nm的波段被稱為生物成像的"近紅外窗口",因此近紅外熒光染料的開發(fā)對生物醫(yī)學的發(fā)展起著極大的推進作用。然而實際可用的近紅外染料數(shù)量少,且有著諸多的缺點,例如菁染料化學穩(wěn)定性和光穩(wěn)定性較差,氟硼二吡咯染料溶解性難以滿足要求。目前大多數(shù)近紅外染料的最大發(fā)射波長集中在650-820 nm范圍內(nèi),處于820-900 nm范圍內(nèi)的染料鮮有報道,此波長范圍內(nèi)的染料有著重要的學術(shù)研究和實際應(yīng)用價值。本課題組近期在近紅外染料的設(shè)計與合成中取得了突破,首次報道了二苯并碳羅丹明的母核結(jié)構(gòu);基于該母核的染料ECX其最大吸收波長可以達到880 nm,ECX有著比該波長范圍內(nèi)其他染料更為優(yōu)越的化學和光學性質(zhì);ECX具有良好的生物兼容性且成功應(yīng)用到細胞成像中。該課題正是在此工作基礎(chǔ)上,對新開發(fā)的染料母核進行修飾,合成了一系列新型近紅外熒光染料ECY;隨后對它們的光物理性質(zhì)和化學穩(wěn)定性進行測試,最后把ECY染料連接到靶向基團上實現(xiàn)了對腫瘤細胞的識別,最終利用熒光成像和光聲成像技術(shù)對腫瘤組織進行成像。本課題驗證了 ECY染料在近紅外區(qū)域的吸收和發(fā)射,同時證明了 ECY染料具有良好的化學和光學性質(zhì),具備生物兼容性,在熒光成像和光聲成像中作為造影劑有可觀的應(yīng)用前景。
[Abstract]:Fluorescent dyes are widely used in biomedical fields, such as detection, labeling, photodynamic therapy, photothermal ablation and so on. The wavelength of near-infrared light is longer than that of ordinary visible light, its Rayleigh scattering effect is smaller, and it has better tissue penetration. The band of 650-900 nm which is interfered by the background signal of biological tissue is called the "near infrared window" of biological imaging, so the development of near infrared fluorescent dyes plays an important role in the development of biomedicine. However, the practical use of near infrared dyes is small and has many shortcomings, such as the poor chemical stability and photostability of cyanine dyes, the solubility of fluorinated boron dipyrrole dyes is difficult to meet the requirements. At present, the maximum emission wavelengths of most near infrared dyes are concentrated in the range of 650-820 nm, and the dyes in the range of 820-900 nm are rarely reported. The dyes in this wavelength range have important academic research and practical application value. Recently, our team has made a breakthrough in the design and synthesis of near infrared dyes, and reported for the first time the parent nuclear structure of dibenzo carbon rhodamine. The maximum absorption wavelength of ECX based on the parent nucleus can reach 880 nm. ECX has better chemical and optical properties than other dyes in this wavelength range. ECX has good biological compatibility and has been successfully applied to cell imaging. On the basis of this work, a series of novel near infrared fluorescent dyes ECY were synthesized by modifying the newly developed dye mother nuclei, and their photophysical properties and chemical stability were tested. Finally, the ECY dye was connected to the target group to realize the recognition of tumor cells, and finally the tumor tissue was imaged by fluorescence imaging and photoacoustic imaging. In this paper, the absorption and emission of ECY dyes in near infrared region are verified, and it is proved that ECY dyes have good chemical and optical properties and biological compatibility. It has a promising future as a contrast agent in fluorescence imaging and photoacoustic imaging.
【學位授予單位】：華東理工大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TQ617.3

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