人體組織偏振參數(shù)高分辨成像方法與系統(tǒng)研究
發(fā)布時(shí)間:2019-04-17 18:32
【摘要】:光學(xué)偏振參數(shù)成像技術(shù)有別于傳統(tǒng)光學(xué)成像,其通過對多組偏振光強(qiáng)圖像進(jìn)行算法反演,提取出偏振參數(shù)進(jìn)行成像,能夠反映被測介質(zhì)的結(jié)構(gòu)和光學(xué)信息,具有提高成像分辨率的潛力。近年來在生物醫(yī)學(xué)領(lǐng)域、天文學(xué)、大氣遙感學(xué)及材料學(xué)等領(lǐng)域開展了大量的應(yīng)用研究并取得了顯著成果。本論文依據(jù)光波偏振參數(shù)成像的基本理論,推導(dǎo)了樣品的光波參數(shù)消光角和相位延遲量、出射光Stokes矢量、Jones矩陣元、Muller矩陣元及Mueller矩陣元分解參數(shù)的表達(dá)式,并通過Matlab實(shí)現(xiàn)參數(shù)的算法反演。并通過相關(guān)硬件搭建和軟件編寫,設(shè)計(jì)和實(shí)現(xiàn)了偏振參數(shù)成像的自動(dòng)化測量系統(tǒng);谠撓到y(tǒng)的自動(dòng)化調(diào)制模塊提出了一種標(biāo)定波片快軸的簡易方法,并解釋了系統(tǒng)中圓偏檢偏器內(nèi)波片快軸方向和檢偏器通光軸方向夾角設(shè)定原因。對人體大腸癌生物組織樣本進(jìn)行實(shí)驗(yàn)測量,發(fā)現(xiàn)Jones矩陣元參數(shù)成像分辨率要高于傳統(tǒng)光學(xué)成像分辨率,并且Mueller矩陣元及Mueller矩陣參數(shù)分解對于癌變區(qū)域和健康區(qū)域具有較好的區(qū)分能力,能夠輔助醫(yī)生診斷,具有一定的臨床醫(yī)學(xué)價(jià)值。
[Abstract]:The optical polarization parameter imaging technology is different from the traditional optical imaging technology. It can reflect the structure and optical information of the measured medium by inverting the polarization intensity images and extracting the polarization parameters, which can reflect the structure and optical information of the measured medium. It has the potential to improve imaging resolution. In recent years, a large number of applied studies have been carried out in biomedical field, astronomy, atmospheric telepathy and material science, and remarkable achievements have been made. In this paper, according to the basic theory of optical wave polarization parameter imaging, the expressions of extinction angle and phase delay of light wave parameter, Stokes vector of outgoing light, Jones matrix element, Muller matrix element and Mueller matrix element decomposition parameter are derived. The algorithm inversion of parameters is realized by Matlab. The automatic measurement system of polarization parameter imaging is designed and realized by hardware construction and software programming. Based on the automatic modulation module of the system, a simple method for calibrating the fast axis of the wave plate is proposed, and the reasons for setting the angle between the fast axis of the wave plate and the direction of the optical axis of the polarizer in the circular polarizer are explained. Experimental measurements of human colorectal cancer biological tissue samples show that the resolution of Jones matrix meta-parameter imaging is higher than that of traditional optical imaging. Moreover, Mueller matrix element and Mueller matrix parameter decomposition have better ability to distinguish canceration region from healthy area, can assist doctors to diagnose, and have certain clinical medical value.
【學(xué)位授予單位】:南京理工大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2017
【分類號】:O436.3
本文編號:2459687
[Abstract]:The optical polarization parameter imaging technology is different from the traditional optical imaging technology. It can reflect the structure and optical information of the measured medium by inverting the polarization intensity images and extracting the polarization parameters, which can reflect the structure and optical information of the measured medium. It has the potential to improve imaging resolution. In recent years, a large number of applied studies have been carried out in biomedical field, astronomy, atmospheric telepathy and material science, and remarkable achievements have been made. In this paper, according to the basic theory of optical wave polarization parameter imaging, the expressions of extinction angle and phase delay of light wave parameter, Stokes vector of outgoing light, Jones matrix element, Muller matrix element and Mueller matrix element decomposition parameter are derived. The algorithm inversion of parameters is realized by Matlab. The automatic measurement system of polarization parameter imaging is designed and realized by hardware construction and software programming. Based on the automatic modulation module of the system, a simple method for calibrating the fast axis of the wave plate is proposed, and the reasons for setting the angle between the fast axis of the wave plate and the direction of the optical axis of the polarizer in the circular polarizer are explained. Experimental measurements of human colorectal cancer biological tissue samples show that the resolution of Jones matrix meta-parameter imaging is higher than that of traditional optical imaging. Moreover, Mueller matrix element and Mueller matrix parameter decomposition have better ability to distinguish canceration region from healthy area, can assist doctors to diagnose, and have certain clinical medical value.
【學(xué)位授予單位】:南京理工大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2017
【分類號】:O436.3
【參考文獻(xiàn)】
相關(guān)期刊論文 前1條
1 陰亞芳,方強(qiáng),劉毓;偏振度測試方法的研究[J];光通信研究;2005年04期
,本文編號:2459687
本文鏈接:http://sikaile.net/shoufeilunwen/benkebiyelunwen/2459687.html
最近更新
教材專著