本文選題：廣義偽氨基酸組成 + 數(shù)值刻畫��； 參考：《渤海大學》2017年碩士論文

【摘要】：隨著人類基因組計劃與其它生物基因組測序工作的相繼實施和完成,生物學數(shù)據(jù)呈指數(shù)增長,生物學研究的重點也由積累數(shù)據(jù)轉(zhuǎn)化為分析解釋這些呈指數(shù)增長的數(shù)據(jù),生物信息學便應(yīng)運而生。生物序列的比較與分析技術(shù)在生物信息學的領(lǐng)域里扮演著越來越重要的角色,而要發(fā)展這項技術(shù)關(guān)鍵的一步就是確定一個適當?shù)姆椒▉肀硎旧镄蛄�。本文針對這一問題在蛋白質(zhì)的序列表示方面進行研究,具體內(nèi)容如下:基于氨基酸3個重要的物理化學性質(zhì),將一條蛋白質(zhì)原始序列約化成一條6字母序列,然后提取出一組反應(yīng)整體和局部序列序信息的元素。之后把這些元素和20種天然氨基酸在序列出現(xiàn)的頻率結(jié)合起來,從而構(gòu)造出一個(21+λ)維特征向量來刻畫蛋白質(zhì)序列。在系統(tǒng)發(fā)育分析和DNA結(jié)合蛋白識別方面的應(yīng)用證實了我們所提方法的有效性。
[Abstract]:With the implementation and completion of the Human Genome Project and the sequencing of other biological genomes, biological data have increased exponentially, and the emphasis of biological research has been transformed from accumulating data to analyzing and explaining the exponential growth of these data. Bioinformatics came into being. The technology of biological sequence comparison and analysis plays an increasingly important role in the field of bioinformatics, and the key step to develop this technology is to determine an appropriate method to represent biological sequence. In this paper, the sequence representation of proteins is studied. The main contents are as follows: based on the three important physicochemical properties of amino acids, a protein original sequence is reduced to a 6-letter sequence. Then a set of elements that respond to global and local sequence information are extracted. Then we combine these elements with the frequency of 20 kinds of natural amino acids in the sequence and construct a (21 位) dimensional eigenvector to characterize the protein sequence. Applications in phylogenetic analysis and DNA-binding protein recognition confirm the effectiveness of our proposed method.
【學位授予單位】：渤海大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：Q51;Q811.4

【參考文獻】

相關(guān)期刊論文 前1條

1 馬飛,武耀廷,許曉風;遺傳密碼子和氨基酸若干物理化學特性的相關(guān)性研究[J];安徽農(nóng)業(yè)大學學報;2003年04期

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本文編號：2069165