本文選題：注意偏向 + 雙相障礙�。� 參考：《深圳大學(xué)》2017年碩士論文

【摘要】：注意偏向(Attention bias)是指一種有選擇性地注意某類信息的傾向,注意偏向作為認(rèn)知功能的重要成分,一直以來備受關(guān)注,也被很多研究者認(rèn)為在情緒障礙的發(fā)生、發(fā)展以及維持中起重要作用。近年來,大量研究表明抑郁個(gè)體存在對(duì)負(fù)性情緒信息的注意偏向。而在臨床工作中常被誤診為抑郁癥的雙相抑郁情感障礙的注意偏向研究尚還缺乏。因此,尋找可以區(qū)分單、雙相抑郁障礙在不同情緒的注意偏向上腦電特征的差異,有利于指導(dǎo)臨床診斷與治療。本文的研究目的是探討單相抑郁與雙相抑郁患者在情緒的注意偏向上是否有不同特點(diǎn),進(jìn)一步明確抑郁患者對(duì)不同情緒信息的注意偏向機(jī)制,具體表現(xiàn)為注意警覺還是注意滯留亦或是兩者皆有,為了尋找可以鑒別單、雙相抑郁障礙的神經(jīng)電生理指標(biāo)。本研究采用事件相關(guān)電位儀記錄17名單相抑郁患者、19名雙相抑郁患者和22名正常對(duì)照者在操作情緒Stroop任務(wù)下的EEG信號(hào)。采用Brain Vision Analyzer 2.0和BESA Research 6.0軟件進(jìn)行預(yù)處理及SPSS 19.0軟件進(jìn)行統(tǒng)計(jì)分析,得出相應(yīng)的EPN和P300成分波幅和潛伏期的值及頭皮電位分析圖和ERP總平均波形圖,比較單、雙相抑郁患者組與正常對(duì)照組的腦電情況。主要的結(jié)果包括:(1)行為學(xué)研究顯示單、雙相抑郁組相比于正常組,對(duì)不同面部表情圖片顏色命名的平均反應(yīng)時(shí)延長(zhǎng);三組被試均對(duì)悲傷面部表情反應(yīng)時(shí)縮短。(2)ERP統(tǒng)計(jì)結(jié)果顯示在高興和中性面部表情條件下,單、雙相抑郁患者組相比于正常組的EPN潛伏期縮短;在悲傷情緒條件下,單、雙相抑郁患者組相比于正常組的P300波幅減小、潛伏期延長(zhǎng);在高興情緒條件下,雙相抑郁組相比于單相抑郁組的EPN潛伏期縮短。(3)單雙相抑郁患者組相比于正常組操作情緒Stroop任務(wù)時(shí)的額區(qū)活性增強(qiáng)。這些發(fā)現(xiàn)總的來說可以歸納為:(1)單、雙相抑郁患者都存在認(rèn)知加工速度受損,對(duì)悲傷面部表情的注意偏向,進(jìn)一步表現(xiàn)出對(duì)悲傷情緒的注意警覺。(2)單、雙相患者組存在對(duì)悲傷面部表情的認(rèn)知缺陷,具體表現(xiàn)為相比于中性刺激P300波幅增大。(3)單相抑郁患者對(duì)悲傷面部表情既表現(xiàn)為注意警覺,又有注意滯留。(4)雙相抑郁患者對(duì)高興面部表情表現(xiàn)為注意警覺,體現(xiàn)在EPN潛伏期比單相抑郁患者縮短。
[Abstract]:Attention bias is a kind of tendency to pay attention to some kind of information selectively. Attention bias, as an important component of cognitive function, has been paid close attention to all along, and has been regarded by many researchers as an important factor in the occurrence of emotional disorders. Development and maintenance play an important role. In recent years, a large number of studies have shown that depressed individuals tend to pay attention to negative emotional information. However, the study of attention bias of bipolar depression affective disorder which is often misdiagnosed as depression in clinical work is still lacking. Therefore, finding out the difference of attention bias in different emotions between single and bipolar depression disorder is helpful to guide clinical diagnosis and treatment. The purpose of this study is to explore whether there are different characteristics of emotional attention bias between monophasic and bipolar depression patients, and to further clarify the attention bias mechanism of depression patients to different emotional information. In order to identify the single bipolar depressive disorder neuroelectrophysiologic indexes were found in order to find out whether attention alertness or attentional retention or both existed. In this study, event-related potentiometer was used to record the EEG signals of 19 bipolar depression patients and 22 normal controls under the task of manipulating emotional Stroop. Brain Vision Analyzer 2.0 and BESA Research 6.0 software were used to pre-process and SPSS 19.0 software for statistical analysis. The corresponding values of amplitude and latency of EPN and P300 components, scalp potential analysis and ERP total average waveform were obtained. EEG in bipolar depression group and normal control group. The main results included: (1) Behavioral studies showed that the average response time to different facial expressions was significantly longer in the single, bipolar depression group than in the normal group; The results showed that the latency of EPN in the patients with single and bipolar depression was shorter than that in the normal group under the condition of happy and neutral facial expressions, while in the sad mood, the latency of EPN in the patients with single and bipolar depression was shorter than that in the normal group, while in the sad mood, the latency of EPN in the patients with single and bipolar depression was significantly shorter than that in the normal group. Compared with the normal group, the amplitude of P300 was decreased and the latency was prolonged in the bipolar depression group. The latency of EPN in bipolar depression group was shorter than that in monophasic depression group. These findings can be summed up as: 1) single, bipolar depression patients had impaired cognitive processing speed, attention bias to sad facial expressions, and further showed attention alert to sad emotions. In the bipolar group, there were cognitive deficits in sad facial expressions, which were manifested as attention alertness to sad facial expressions in patients with monophasic depression compared with neutral stimuli with increased P300 amplitude. There were also attentional retention. 4) the patients with bipolar depression showed attention alertness to happy facial expressions, which showed that the latency of EPN was shorter than that of patients with monophasic depression.
【學(xué)位授予單位】：深圳大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：B842.3

【相似文獻(xiàn)】

相關(guān)會(huì)議論文 前10條

1 張明;甘照宇;鐘智勇;關(guān)念紅;張晉碚;;單雙相抑郁智能損害的對(duì)照研究[A];中國(guó)心理衛(wèi)生協(xié)會(huì)第三屆中青年心理衛(wèi)生學(xué)者學(xué)術(shù)研討會(huì)論文匯編[C];2012年

2 黃樂萍;汪作為;方貽儒;;雙相抑郁的早期危險(xiǎn)因素研究[A];中華醫(yī)學(xué)會(huì)第十次全國(guó)精神醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2012年

3 張明;;單雙相抑郁智能損害的對(duì)照研究[A];中華醫(yī)學(xué)會(huì)第十次全國(guó)精神醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2012年

4 金衛(wèi)東;邢葆平;黃飛華;馮斌;;軟雙相抑郁與中醫(yī)證型[A];第四屆全國(guó)中西醫(yī)結(jié)合心身醫(yī)學(xué)學(xué)術(shù)研討會(huì)論文集[C];2006年

5 金衛(wèi)東;陳炯;陳正昕;馬永春;張江濤;邢葆平;;抗抑郁藥物引起雙相抑郁患者轉(zhuǎn)相的危險(xiǎn)因素研究[A];中華醫(yī)學(xué)會(huì)精神病學(xué)分會(huì)第七屆學(xué)術(shù)年會(huì)論文摘要集[C];2006年

6 賈z嚴(yán)，

本文編號(hào)：1954388