本文選題：海馬 + 前扣帶回　； 參考：《首都師范大學(xué)》2014年碩士論文

【摘要】：研究目的：觀察前扣帶回和海馬CA1區(qū)在非快速眼動(dòng)睡眠時(shí)對(duì)先前學(xué)習(xí)記憶的自發(fā)性再啟動(dòng)特點(diǎn)。方法：應(yīng)用多通道神經(jīng)元放電同步記錄技術(shù),對(duì)學(xué)習(xí)前的基線測(cè)試期、學(xué)習(xí)期和學(xué)習(xí)后非快速眼動(dòng)睡眠進(jìn)行全程記錄,觀察記錄大鼠海馬CA1區(qū)和前扣帶回的神經(jīng)元放電頻率、場(chǎng)電位及神經(jīng)元放電脈沖序列。結(jié)果：習(xí)得前,海馬CA1區(qū)無(wú)論在高頻復(fù)合波階段(Sharp Wave-Ripple Events, SPWR)或是睡眠錠階段都傾向于再啟動(dòng)正確試次,且再啟動(dòng)內(nèi)容主要為氣味編碼階段和獎(jiǎng)賞獲得階段；而前扣帶回神經(jīng)元?jiǎng)t傾向于再啟動(dòng)錯(cuò)誤試次,且對(duì)氣味編碼階段、獎(jiǎng)賞預(yù)期階段和獎(jiǎng)賞獲得階段均有較大程度的再啟動(dòng)。睡眠錠期間發(fā)生的再啟動(dòng)過程較高頻復(fù)合波期間存在一定的延遲。習(xí)得后,無(wú)論是海馬CA1區(qū)或是前扣帶回對(duì)先前學(xué)習(xí)經(jīng)驗(yàn)再啟動(dòng)強(qiáng)度均明顯降低。結(jié)論：非快速眼動(dòng)睡眠時(shí),前扣帶回與海馬CA1區(qū)均參與迷宮任務(wù)的再啟動(dòng)并且存在對(duì)不同學(xué)習(xí)任務(wù)的偏好性再啟動(dòng),前扣帶回對(duì)錯(cuò)誤信息更敏感；SPWR期間再啟動(dòng)發(fā)生較睡眠錠提前,提示再啟動(dòng)發(fā)生時(shí)在海馬與前扣帶回間的信息傳遞方向；再啟動(dòng)強(qiáng)度隨學(xué)習(xí)成績(jī)的提高而降低。
[Abstract]:Aim: to observe the spontaneous reactivation of previous learning and memory in the anterior cingulate gyrus and hippocampal CA1 area during non-rapid eye movement sleep. Methods: the baseline test period, learning period and non-rapid eye movement sleep before and after learning were recorded by multi-channel synchronous recording of neuronal discharges. The frequency of neuronal discharges in CA1 region and anterior cingulate gyrus of rats were observed. Field potential and neuronal discharge pulse sequence. Results: before acquisition, both sharp Wave-Ripple events (SPWRs) and sleep ingots in hippocampal CA1 region tended to start the correct trial again, and the restarting contents were mainly odor coding stage and reward acquisition stage. The anterior cingulate gyrus neurons tended to restart the wrong test, and restarted to a greater extent in the odor coding stage, the reward expectation stage and the reward acquisition stage. The process of restarting during sleep ingot is delayed than that during high frequency composite wave. After acquisition, both the hippocampal CA1 area and the anterior cingulate gyrus significantly decreased the intensity of restarting the previous learning experience. Conclusion: both the anterior cingulate gyrus and hippocampal CA1 are involved in the restarting of labyrinth tasks during non-REM sleep, and there are preference restarts for different learning tasks. The anterior cingulate gyrus was more sensitive to the wrong information and the reboot occurred earlier than the sleep ingot during SPWR, indicating the direction of information transmission between the hippocampus and the anterior cingulate gyrus at the time of restart, and the intensity of reboot decreased with the increase of learning achievement.
【學(xué)位授予單位】：首都師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：B842.3

【共引文獻(xiàn)】

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本文編號(hào)：1822593