本文關(guān)鍵詞：應(yīng)激性抑郁樣行為發(fā)生中眶額葉5-HT1A受體對谷氨酸和γ-氨基丁酸的調(diào)節(jié)　出處：《心理學(xué)報(bào)》2015年10期 　論文類型：期刊論文

  更多相關(guān)文章： -羥色胺 谷氨酸 γ-氨基丁酸 抑郁

【摘要】：5-羥色胺(5-hydroxytryptamine,5-HT)在抑郁癥的發(fā)生及治療中起著極其重要的作用,谷氨酸(glutamic acid,Glu)過度釋放是應(yīng)激性抑郁發(fā)生的重要原因。為了證明應(yīng)激性抑郁樣行為發(fā)生中眶額葉(orbitofrontal cortex,OFC)5-HT1A受體是否通過對Glu和γ-氨基丁酸(gamma-aminobutyric acid,GABA)的調(diào)節(jié)而發(fā)揮作用。本研究通過建立慢性不可預(yù)見性溫和應(yīng)激(chronic unpredictable mild stress,CUMS)抑郁模型,結(jié)合OFC區(qū)分別微量注射5-HT1A受體激動(dòng)劑8-OH-DPAT和拮抗劑WAY100635,采用糖水偏愛率測試、曠場測試及懸尾測試檢測動(dòng)物的行為學(xué)表現(xiàn),并通過高效液相色譜法(high-performance liquid chromatography,HPLC)分別檢測了OFC區(qū)5-HT、Glu和GABA的含量。結(jié)果顯示,CUMS組和注射WAY100635組大鼠較對照組表現(xiàn)出明顯的抑郁樣行為,且Glu含量顯著升高,但5-HT水平和GABA含量均未有顯著性變化。微量注射8-OH-DPAT后,能夠顯著改善大鼠的抑郁樣行為,且Glu顯著降低,但5-HT水平和GABA含量仍未發(fā)生顯著性變化。結(jié)果表明,慢性不可預(yù)見性溫和應(yīng)激所引起的抑郁樣行為,并不是由于眶額葉5-HT水平的降低,而可能是由于5-HT不能滿足應(yīng)激狀態(tài)下調(diào)節(jié)Glu能神經(jīng)的需要,或可能是OFC區(qū)Glu能神經(jīng)元上5-HT1A受體功能的降低,導(dǎo)致Glu水平過高所致�？纛~葉5-HT1A受體在Glu合成與釋放中發(fā)揮重要調(diào)節(jié)作用。
[Abstract]:Serotonin 5-hydroxytryptamine 5-HT plays an extremely important role in the occurrence and treatment of depression, glutamic acid acid. In order to prove that orbitofrontal cortex is involved in the occurrence of stress-like depressive behavior, excessive release of Glu) is an important cause of stress-induced depression. Whether OFC)5-HT1A receptors pass through Glu and gamma-aminobutyric acid. In this study, chronic unpredictable mild stress was established by establishing chronic unpredictable mild stress. CUMS depression model, 5-HT1A receptor agonist 8-OH-DPAT and antagonist WAY100635 were microinjected into the OFC region, respectively. The sugar water preference rate was measured. The behavior of animals was measured by open field test and tail suspension test, and high-performance liquid chromatography was performed by high performance liquid chromatography (HPLC). The contents of 5-HT-Glu and GABA in the OFC region were determined by HPLC, respectively. Compared with the control group, the CUMS group and the WAY100635 injection group showed obvious depressive behavior, and the content of Glu increased significantly. However, the level of 5-HT and the content of GABA did not change significantly. After microinjection of 8-OH-DPAT, the depressive behavior of rats was significantly improved, and Glu was significantly decreased. The results showed that depression induced by chronic unpredictable mild stress was not due to the decrease of 5-HT level in the orbital frontal lobe. It may be that 5-HT can not meet the need of regulating Glu neurons under stress, or that the function of 5-HT1A receptor in Glu neurons in OFC region is decreased. 5 HT 1A receptor plays an important role in the synthesis and release of Glu.
【作者單位】： 陜西師范大學(xué)生命科學(xué)學(xué)院;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81371512)
【分類號(hào)】：B845
【正文快照】： 1問題提出抑郁癥是一種比較普遍,且危害極大的心理與精神障礙性疾病。單胺類遞質(zhì)失調(diào)學(xué)說是研究抑郁癥發(fā)生機(jī)制及治療的主要理論之一�；诖硕粡V泛使用的一些抗抑郁藥雖能快速增加突觸間隙單胺類遞質(zhì)的濃度,但由于其抗抑郁起效時(shí)間延遲,使得單胺類遞質(zhì)失調(diào)假說不足以解釋抑

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