本文關(guān)鍵詞：心理行為干預(yù)與卵巢癌患者情緒及T淋巴細(xì)胞亞群的動(dòng)態(tài)變化研究，由筆耕文化傳播整理發(fā)布。

【中文題名】: 心理行為干預(yù)與卵巢癌患者情緒及T淋巴細(xì)胞亞群的動(dòng)態(tài)變化研究

【專業(yè)名稱】: [標(biāo)簽:出處]

【學(xué)位年度】: 涉及隱私，隱去***

【論文級別】:

【關(guān)鍵字】:

【作者中文名】【導(dǎo)師】【畢業(yè)學(xué)�！俊井厴I(yè)年份】：涉及隱私，隱去***

【中文摘要】:  

【中文摘要】目的:探討心理行為干預(yù)對卵巢癌患者情緒、T淋巴細(xì)胞亞群的動(dòng)態(tài)變化規(guī)律及干預(yù)效果的影響因素,并進(jìn)一步探討心理行為干預(yù)的最佳時(shí)間。對象與方法:將符合要求的62名卵巢癌患者隨機(jī)分為干預(yù)組和對照組,每組31名。所有患者均在干預(yù)前進(jìn)行基線測評,包括漢密爾頓焦慮量表(HAMA)、抑郁量表(HAMD)、簡易應(yīng)對方式問卷、艾森克人格問卷(EPQ)和抽取靜脈血用免疫組化堿性磷酸酶橋聯(lián)酶標(biāo)法(APAAP)測定T淋巴細(xì)胞亞群的功能。干預(yù)組心理行為干預(yù)持續(xù)三個(gè)月。心理行為干預(yù)第一個(gè)月后測定兩組患者情緒和T淋巴細(xì)胞亞群(CD3 、CD4 、CD8 、CD4 / CD8 )的數(shù)值。心理干預(yù)后第二個(gè)月、第三個(gè)月只測定兩組患者的T淋巴細(xì)胞亞群的數(shù)值。結(jié)果:(1)干預(yù)組與對照組之間干預(yù)前均衡性比較沒有明顯性差異(P>0.05)(年齡、文化程度、職業(yè)、付費(fèi)方式、腫瘤分期、焦慮、抑郁和T淋巴細(xì)胞亞群)。(2)心理行為干預(yù)后,兩組焦慮、抑郁總分干預(yù)前后差值的比較有明顯性差別(P<0.05),干預(yù)組的焦慮和抑郁明顯減輕。(3)心理行為干預(yù)后焦慮、抑郁變化受人格因素的影響人格特質(zhì)中的神經(jīng)質(zhì)與干預(yù)后抑郁有正相關(guān)性,未見神經(jīng)質(zhì)與干預(yù)后焦慮的相關(guān)性。內(nèi)外向與干預(yù)后的焦慮、抑郁得分呈負(fù)相關(guān)。未見焦慮和抑郁與精神質(zhì)相關(guān)。掩飾性與干預(yù)后焦慮有相關(guān)性,未見掩飾性與干預(yù)后抑郁的相關(guān)性。(4)心理行為干預(yù)一個(gè)月后CD3 (55.6±4.7/51.7±6.7,F=26.49)、CD4 (33.483±3.462/32.225±4.543 ,F=6.82)有明顯性進(jìn)步;干預(yù)2個(gè)月后各免疫參數(shù)CD3 (60.967±4.262/51.7±6.7,F=145.8)、CD4 (36.483±3.355/32.225±4.543,F=78.08)、CD8 (29.806±3.458/35.290±6.039,F=70.57)、CD4 / CD8 (1.244±0.218/0.950±0.272,F=102.13)均有明顯變化,且干預(yù)2個(gè)月與3個(gè)月相比各免疫參數(shù)變化不明顯。干預(yù)組與對照組相比,不同時(shí)間點(diǎn)的各種免疫參數(shù)有明顯性差異(P<0. 05),干預(yù)與時(shí)間點(diǎn)見明顯的交互作用(P<0. 05),除CD8 (F=2.95,P>0. 05)外,兩組患者各免疫參數(shù)存在明顯性差異。(5)心理行為干預(yù)后T淋巴細(xì)胞亞群的變化受人格因素的影響神經(jīng)質(zhì)與CD8 正相關(guān),但內(nèi)外向、神經(jīng)質(zhì)和掩飾性與T淋巴細(xì)胞亞群(CD3 、CD4 、CD8 及CD4 / CD8 比值)的相關(guān)性不明顯。(6)影響心理行為干預(yù)效果的多元回回分析影響焦慮干預(yù)效果的因素有消極應(yīng)對、掩飾性、和文化程度。影響抑郁干預(yù)效果的因素有消極應(yīng)對、內(nèi)外向和掩飾性。影響CD3 變化的因素有干預(yù)后抑郁。影響CD4 變化的因素有干預(yù)前焦慮、年齡、付費(fèi)方式和干預(yù)前抑郁。影響CD8 變化的因素有積極應(yīng)對方式、付費(fèi)方式和掩飾性。影響CD4 / CD8 變化的因素有積極應(yīng)對、掩飾性和焦慮。結(jié)論:(1)心理行為干預(yù)能明顯改善卵巢癌患者的焦慮和抑郁情緒。(2)心理行為干預(yù)可以進(jìn)步卵巢癌患者T淋巴細(xì)胞亞群的免疫功能,且心理干預(yù)2個(gè)月后患者免疫功能維持在較高水平。(3)心理行為干預(yù)后影響患者焦慮、抑郁及T淋巴細(xì)胞亞群的因素各不相同。');
【Abstract】 Objective:To examine the effects of psycho-behavioral intervention including educational intervention and progressive muscle relaxation on emotional disorder and the Changes of T lymphocyte subsets in Patients with Ovarian Cancer, and influencing factor, and further explore the best time. Subjects and Methods:62 inpatients were randomly assigned to either intervention group (n=31) or control group (n=31). All patients completed questionnaires including Hamilton Depression rating Scale(HAMD) ,Hamilton Anxiety rating Scale (HAMA), Simple Coping Style Questionnare, Eysenck Personality Questionnaire (EPQ) and immune parameter variables in both groups were measured with Alkaline Phosphatase Anti Alkaline Phosphatase ( APAAP ) technique at baseline assessment. The intervention group patients accepted psycho-behavioral intervention including educational intervention and progressive muscle relaxation for three months from the second chemotherapy. Emotion and coping style and T lymphocyte subsets were measured in all patients one month after psycho-behavioral intervention. T lymphocyte subsets were also measured during two and three months after psycho-behavioral intervention.Results:(1) There were no statistical significance between the intervention group and the control group in age, culture, occupation, pay style, tumor stage and T lymphocyte subsets at baseline assessment(p>0.05).(2) There were statistical significance between the intervention group and the control group in depression and anxiety (p

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  本文關(guān)鍵詞：心理行為干預(yù)與卵巢癌患者情緒及T淋巴細(xì)胞亞群的動(dòng)態(tài)變化研究，由筆耕文化傳播整理發(fā)布。