蘿卜硫烷對腦線粒體的影響:機理觀點和未來發(fā)展方向(英文)
發(fā)布時間:2021-05-06 10:57
有機硫化物蘿卜硫烷(SFN)是一種有效的細胞保護劑,在體外和體內(nèi)實驗模型中均可促進抗氧化、抗炎、抗糖化和抗菌作用。因為氧化磷酸化系統(tǒng)的存在,所以線粒體是三磷酸腺苷(ATP)的主要產(chǎn)生部位。同時,線粒體也是具核人體細胞中產(chǎn)生活性氧的主要場所。線粒體損傷在多種人類疾病中起著重要作用,包括神經(jīng)退行性病變和代謝異常。本文描述和討論了SFN調(diào)節(jié)哺乳動物細胞中線粒體功能和動力學的作用和機理,以及其對腫瘤細胞中線粒體促凋亡途徑的促進作用。SFN對線粒體的調(diào)節(jié)作用使得它在一定程度上被認為是一種細胞保護劑。本文還指出了幾個需要通過進一步實驗解決的問題,即未來的可能研究方向,這可能會對該領(lǐng)域的研究人員具有指導作用。
【文章來源】:Journal of Zhejiang University-Science B(Biomedicine & Biotechnology). 2020,21(04)SCICSCD
【文章頁數(shù)】:17 頁
【文章目錄】:
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文編號:3171802
【文章來源】:Journal of Zhejiang University-Science B(Biomedicine & Biotechnology). 2020,21(04)SCICSCD
【文章頁數(shù)】:17 頁
【文章目錄】:
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文編號:3171802
本文鏈接:http://sikaile.net/projectlw/swxlw/3171802.html
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