蘿卜硫烷對(duì)腦線粒體的影響:機(jī)理觀點(diǎn)和未來(lái)發(fā)展方向(英文)
發(fā)布時(shí)間:2021-05-06 10:57
有機(jī)硫化物蘿卜硫烷(SFN)是一種有效的細(xì)胞保護(hù)劑,在體外和體內(nèi)實(shí)驗(yàn)?zāi)P椭芯纱龠M(jìn)抗氧化、抗炎、抗糖化和抗菌作用。因?yàn)檠趸姿峄到y(tǒng)的存在,所以線粒體是三磷酸腺苷(ATP)的主要產(chǎn)生部位。同時(shí),線粒體也是具核人體細(xì)胞中產(chǎn)生活性氧的主要場(chǎng)所。線粒體損傷在多種人類疾病中起著重要作用,包括神經(jīng)退行性病變和代謝異常。本文描述和討論了SFN調(diào)節(jié)哺乳動(dòng)物細(xì)胞中線粒體功能和動(dòng)力學(xué)的作用和機(jī)理,以及其對(duì)腫瘤細(xì)胞中線粒體促凋亡途徑的促進(jìn)作用。SFN對(duì)線粒體的調(diào)節(jié)作用使得它在一定程度上被認(rèn)為是一種細(xì)胞保護(hù)劑。本文還指出了幾個(gè)需要通過(guò)進(jìn)一步實(shí)驗(yàn)解決的問(wèn)題,即未來(lái)的可能研究方向,這可能會(huì)對(duì)該領(lǐng)域的研究人員具有指導(dǎo)作用。
【文章來(lái)源】:Journal of Zhejiang University-Science B(Biomedicine & Biotechnology). 2020,21(04)SCICSCD
【文章頁(yè)數(shù)】:17 頁(yè)
【文章目錄】:
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文編號(hào):3171802
【文章來(lái)源】:Journal of Zhejiang University-Science B(Biomedicine & Biotechnology). 2020,21(04)SCICSCD
【文章頁(yè)數(shù)】:17 頁(yè)
【文章目錄】:
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文編號(hào):3171802
本文鏈接:http://sikaile.net/projectlw/swxlw/3171802.html
最近更新
教材專著