近年來,在納米尺度上構(gòu)建具有高負(fù)載能力、有序介孔孔道和表面改性的中空載體是藥物遞送的研究熱點(diǎn)。本論文采用阿維菌素（avermectin,AVM）和氯蟲苯甲酰胺（chlorantraniliprole,CLAP）作為模式藥物,分別制備了不同尺寸和釋放性能的功能化中空介孔二氧化硅納米粒子（Hollow20mesoporous20silica,HMS）,負(fù)載模式藥物后,采用α-環(huán)糊精作為封堵劑封閉HMS表面的介孔,制備了能夠在昆蟲中腸中響應(yīng)酶的刺激從而釋放藥物的控制釋放劑型（controlled20release20formulation,CRF）。主要結(jié)果如下:以不同尺寸的聚苯乙烯膠束為模板,正硅酸四乙酯在其表面水解凝聚成二氧化硅,經(jīng)600℃高溫煅燒去除聚苯乙烯模板,得到三種尺寸（14020nm,40020nm和1500nm）的中空介孔二氧化硅。應(yīng)用N-苯基氨基丙基三甲氧基硅烷對HMS表面進(jìn)行改性,以擴(kuò)散的方式將農(nóng)藥負(fù)載至改性的HMS中。然后,采用α-環(huán)糊精作為封堵劑與苯胺基發(fā)生作用,封閉HMS表面介孔,從而制備出控制釋放劑型。通過透射電子顯微鏡（transmission20electro... 

【文章來源】：華中農(nóng)業(yè)大學(xué)湖北省 211工程院校 教育部直屬院校

【文章頁數(shù)】：103 頁

【學(xué)位級(jí)別】：博士

【文章目錄】：
Abstract
摘要
List of Abbreviations
Chapter 1. Literature review
    1 Introduction
        1.1 Drug-delivery
        1.2 Drug-carriers
        1.3 Pesticides controlled release formulation
        1.4 Silica-based nano-carriers' role in drug-delivery
        1.5 Porous Silica Nanoparticles role in pesticides formulation
        1.6 Porous Silica Nanoparticles surface functionalization
        1.7 The selected pesticides
        1.8 Objective of study
Chapter 2. Synthesis of three different sizes of hollow mesoporous silica carriers for controlled release of pesticides
    1 Introduction
    2 Materials and Methods
        2.1 Materials
        2.2 Characterization
    3 Methods
        3.1 Synthesis of CRFs
        3.2 HMS surface functionalization
        3.3 Loading cargo molecules and sealing HMS pores
    4 CRFs characterization
        4.1 CRFs thermal and light stability assay
        4.2 Release figuration from CRFs under various stresses
        4.3 Statistical analysis of controlled release data
        4.4 Assay of biological activities of Pesticides-CRFs
    5 Results
        5.1 CRF fabrication
        5.2 TEM and SEM observations
        5.3 Fourier transmission infrared spectroscopy
        5.4 N_2 adsorption-desorption isotherms
        5.5 Dynamic light scattering (DLS)
        5.6 Drug loading efficiency (DLE)
        5.7 Thermal and light stability of CLAP-CRFs and AVM-CRFs
        5.8 CLAP-CRF and AVM-CRF controlled release kinetics
        5.9 CRFs biological activity
Summary
References
Appendixes
    Appendix I
    Appendix II
    Appendix III
Publications
Acknowledgements



本文編號(hào)：3178943