【摘要】：目的探討海南地區(qū)類鼻疽伯克霍爾德菌(BP)對常用抗生素的敏感性。方法以2008年1月—2013年3月在海南地區(qū)患者中分離的101株非重復(fù)類鼻疽伯克霍爾德菌作為研究對象,采用E-test法對目前國際上常用于治療類鼻疽的抗生素進(jìn)行藥物敏感試驗分析。結(jié)果本實驗收集的101株類鼻疽菌中主要是以敗血癥為主,共有60人(59.4%),其次是肺部感染22人(21.8%),傷口及皮膚軟組織感染有17人(16.8%),尿路感染2人(2.0%),受試者總死亡率為17.8%(18/101),其中72.2%(13/18)的死亡患者見于敗血癥患者。體外藥敏試驗結(jié)果顯示,本次分離的所有類鼻疽對美羅培南、亞胺培南、左氧氟沙星、頭孢他啶和阿莫西林/克拉維酸均顯示良好的敏感性,敏感率分別為100%、100%、94.4%、92.1%和90.1%。對四環(huán)素和復(fù)方磺胺甲VA唑的敏感率分別為85.1%和84.2%。結(jié)論本研究和其他地區(qū)的報道都證實了類鼻疽伯克霍爾德菌對目前國際上常用于治療該疾病的抗生素呈現(xiàn)良好的敏感性,其中以亞胺培南和美羅培南的敏感性最好,可作為治療的首選。
[Abstract]:Objective to investigate the sensitivity of Burkholderia gangrenosum (BP) to common antibiotics in Hainan. Methods from January 2008 to March 2013, 101 strains of Berkholderia gangrenoides isolated from patients in Hainan area were selected as the object of study. E-test method was used to analyze the drug sensitivity test of antibiotics commonly used in the treatment of gangrene in the world. Results among the 101 strains of gangrene, 60 cases (59.4%) were septicemia, 22 cases (21.8%) were pulmonary infection, 17 cases (16.8%) were wound, skin and soft tissue infection, 2 cases (2.0%) were urinary tract infection, and the total mortality rate was 17.8% (18 鈮，

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