【摘要】：目的:觀察人臍帶間充質(zhì)干細(xì)胞移植治療慢性失眠的有效性和安全性。方法:選擇慢性失眠病人39例,隨機(jī)分為移植組19例,對(duì)照組20例,移植組給予人臍帶間充質(zhì)干細(xì)胞移植治療1次,對(duì)照組采用阿普唑侖口服1月,兩組患者均采用SF-36健康調(diào)查簡(jiǎn)表和匹茲堡睡眠質(zhì)量指數(shù)來(lái)評(píng)價(jià)臨床療效,兩組患者均隨訪觀察12個(gè)月。結(jié)果:1細(xì)胞移植組患者在細(xì)胞移植治療后1個(gè)月生活質(zhì)量評(píng)分和睡眠質(zhì)量評(píng)分明顯好于治療前,并在后續(xù)的隨訪中持續(xù)好于治療前;對(duì)照組口服阿普唑侖治療后2周睡眠質(zhì)量評(píng)分即開(kāi)始明顯好于治療前,但治療后3個(gè)月患者的生活質(zhì)量及睡眠質(zhì)量評(píng)分出現(xiàn)下降,且同治療前無(wú)差異,并持續(xù)到隨訪結(jié)束;2兩組比較發(fā)現(xiàn),治療后2周,對(duì)照組的睡眠質(zhì)量評(píng)分明顯高于移植組,治療后1個(gè)月兩組睡眠質(zhì)量和生活質(zhì)量評(píng)分無(wú)差異,治療后2個(gè)月細(xì)胞移植組的睡眠質(zhì)量評(píng)分明顯好于對(duì)照組,并持續(xù)到隨訪結(jié)束。治療后3個(gè)月移植組的生活質(zhì)量評(píng)分明顯好于對(duì)照組,并持續(xù)到隨訪結(jié)束;3阿普唑侖停藥后對(duì)照組患者有80%出現(xiàn)失眠癥狀的反彈,而細(xì)胞移植組患者經(jīng)一次治療患者的睡眠質(zhì)量和生活質(zhì)量改善作用可持續(xù)12個(gè)月,并且無(wú)明顯不良反應(yīng)。結(jié)論:人臍帶間充質(zhì)干細(xì)胞靜脈輸注治療可顯著改善慢性失眠患者的睡眠質(zhì)量和生活質(zhì)量,移植后1個(gè)月起效,一次治療作用可持續(xù)達(dá)1年之久。
[Abstract]:Objective: to observe the efficacy and safety of human umbilical cord mesenchymal stem cell transplantation in the treatment of chronic insomnia. Methods: Thirty-nine patients with chronic insomnia were randomly divided into transplantation group (n = 19) and control group (n = 20). Human umbilical cord mesenchymal stem cell transplantation was given once in the transplantation group and alprazolam was administered orally for one month in the control group. SF-36 health survey summary and Pittsburgh sleep quality index were used to evaluate the clinical efficacy in both groups. The patients in both groups were followed up for 12 months. Results the scores of quality of life and sleep quality of the patients in the cell transplantation group 1 month after cell transplantation were significantly better than those before treatment, and continued to be better than those before treatment in follow-up. The scores of sleep quality at 2 weeks after oral alprazolam treatment in the control group were significantly better than those before treatment, but the quality of life and sleep quality scores of the patients at 3 months after treatment decreased, and there was no difference between the two groups before and after treatment. Two weeks after treatment, the sleep quality score of the control group was significantly higher than that of the transplantation group, and there was no difference in sleep quality and quality of life score between the two groups one month after treatment. Two months after treatment, the sleep quality score of the cell transplantation group was significantly better than that of the control group, and continued until the end of follow-up. The quality of life score in the transplantation group was significantly better than that in the control group 3 months after treatment, and 80% of the patients in the control group rebounded from insomnia until the end of follow-up. In the cell transplantation group, the improvement of sleep quality and quality of life lasted 12 months, and there was no significant adverse reaction. Conclusion: intravenous infusion of human umbilical cord mesenchymal stem cells can significantly improve sleep quality and quality of life in patients with chronic insomnia.
【作者單位】： 浙江大學(xué)醫(yī)學(xué)院;浙江武警總隊(duì)醫(yī)院;
【分類號(hào)】：R740

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