本文關(guān)鍵詞：地特胰島素注射液的臨床效果和經(jīng)濟(jì)學(xué)評價研究綜述，由筆耕文化傳播整理發(fā)布。

《Journal of Hebei Medical University》 2014-04

Get Latest Update

EVALUATION ON SAFETY AND EFFECTIVENESS ABOUT INSULIN GLARGINE INJECTION AT DIFFERENT TIME IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

YU Lihong;LI Chunhui;SU Shengou;ZHOU Hong;Department of Endocrinology,the Second Hospital of Hebei Medical University;  

Objective To evaluate the safety and the effectiveness about subcutaneous injection of insulin glargine at different time in patients with type 1 diabetes mellitus.Methods Clinical data about 36 inpatients with type 1 diabetes from our hospital were collected.Twelve patients were treated with insulin glargine combined with biosynthetic human insulin,and the remaining 24 patients were treated with insulin glargine combined widi insulin aspart.Subcutaneous injection time of insulin glargine was changed from 22;00 to 18;00.Observation was made in fast blood glucose(FBG),postprandial 2 h blood glucose(2hPBG),blood glucose before lunch,the doses of biosynthetic human insulin or insulin aspart and insulin glargine during 3 days before and after variation of injection time,.Results In the patients treated with insulin glargine combined with biosynthetic human insulin,compared with before variation of injection time,FBG and lunch 2hPBG were decreased(P 0.05),moderate hypoglycemia(blood glucose≤2.8 mmol/L) incidents before lunch were significantly reduced(P 0.05).There was no significant difference in conventional hypoglycemia(blood glucose ≤3.9 mmol/L) incidents before lunch(P 0.05).In the patients treated with insulin glargine combined with insulin aspart,compared with before variation of injection time,FBG and lunch 2hPBG were decreased(P 0.05,P 0.01).Conventional hypoglycemia(blood glucose≤3.9 mmol/L) incidents and moderate hypoglycemia(blood glucose≤2.8 mmol/L) incidents before lunch were significantly reduced(P 0.01).There were no significant differences in breakfast and supper 2hPBG,the doses of biosynthetic human insulin or insulin aspart and insulin glargine(P 0.05).Conclusion The result suggests that variation of insulin glargine injection time from 22;00 to 18:00 can stabilize rapidly blood glucose in patients with type 1 diabetes mellitus,even without increasing the doses of insulin.

【Key Words】：
【CateGory Index】： R587.1

CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.

【Citations】

Chinese Journal Full-text Database 1 Hits

1 Shen Li(Kunshan First People's Hospital,Kunshan,Jiangsu,China 215300);Efficacy of Insulin Glargine for Treating Newly-Diagnosed Type 2 Diabetes in 44 Cases[J];China Pharmaceuticals;2010-15

【Co-citations】

Chinese Journal Full-text Database 10 Hits

1 HE Rong-zhong.ShiJie People's Hospital of Dongguan City,Guangdong,Dongguan 523290,China;Effect of comprehensive community intervention on patients with type-2 diabetes mellitus[J];Chinese Journal of Clinical Rational Drug Use;2009-10

2 QIN Jian-ming.The People's of Hospital of Hechi City,Guangxi,Hechi 547000,China;Correlation between drug compliance and glycemic control in patients with type 2 diabetes mellitus[J];Chinese Journal of Clinical Rational Drug Use;2010-11

3 WANG Qiong;WEI Yong-lan;XIA Jin-ji;Chengdu Center for Disease Control and Prevention;;Effectevaluation of diabetes mellitus control in hospital and community health centre in Chengdu[J];Sichuan Medical Journal;2013-09

4 Liu Bo,Zhang Xiaoyan(Air Force General Hospital,Beijing 100142,China);Application of insulin glargine in therapy of senile patients with type 2 diabetes mellitus[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2009-32

5 JIANG Libo, LU Yanchun (Department of Pharmacy, Zhongtang Hospital of Dongguan City, Guangdong Province, Dongguan 523220, China);Clinical observation on compliance in patients with diabetes mellitus[J];China Medical Herald;2009-18

6 ;地特胰島素注射液的臨床效果和經(jīng)濟(jì)學(xué)評價研究綜述[J];China Journal of Pharmaceutical Economics;2010-03

7 YANG Zheng,CHEN Jun-jian,SUN Yi-ping,et al.Departmetn of Endolrinology,The Poeple’s Hospital of Danxi Distriction Zhenjiang City,Zhenjiang 212028,China;The observation of insulin detemir treatment of early diagnosis of type 2 diabetes and cirrhosis[J];Chinese Journal of Modern Drug Application;2012-17

8 LIU Xia;ZHANG Xin-juan;SHI Hai-hong;The Hospital of Jinan;;Chronic Diabetes Community Prevention Intervention Observation[J];Medical Innovation of China;2013-27

9 HUANG Zhiling;Department of Comprehensive Internal Medicine, The 81st Rehabilitation Center of Sichuan;;Application and clinical efficacy of self-nursing model in patients with typeⅡ diabetes[J];Journal of Clinical Medicine in Practice;2013-22

10 Wang Lanying;Li Hong;Xue Ling;Peng Jianxia;Yan Hui;Department of Pediatrics,Tangshan Municiapl Maternal and Child Health Care Hospital;College of Public Health,Hebei Union University;;Observation on Efficacy and Safety of Insulin Glargine with Different Administration Time for Treating type 1 Diabetes[J];China Pharmaceuticals;2014-04

【Secondary Citations】

Chinese Journal Full-text Database 5 Hits

1 Zhou Jin Wang Zhongdi (Nursing department,Nedical college of Shaoxing literature and science University,Zhejian,Shaoxin 312000);Study on the reason and strategy of drug compliance for elder diabetics[J];Journal of Nurses Training;2002-01

2 Du Miaocong, Lü Yifeng, Li Min, et al(Taishan Sanatorium of Shandong Province, Shandong 271000 China);Causative Analysis on Low Therapeutic Compliance of Diabetic Patients and Its Nursing Countermeasures[J];;2003-12

3 Song Yuying,Huang Chengfeng,Zhou Dan,et al(Third People's Hospital of Jingzhou City Hubei Province, Hubei 434001 China);A Study on Applying of “Barrel Principle" in Health Education for Patients With Diabetes Mellitus[J];;2004-01

4 PanChangyu;Lu Juming;Tian Hui;et al.( Department ofEndocrinology, Chinese PLA Generof Hospital, Beijing100853).;Epidemiology of adult Diabetes mellites in a popula-tion of capital iron and steel company in Beijing[J];NATIONAL MEDICAL JOURNAL OF CHINA;1995-07

5 BU Shi, XING Xiao-yan, WANG Na, ZHAO Wen -hui, YANG Wen-ying*. Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China;Evaluation of the Efficacy and Safety of Once Daily Injection of Glargine Combined with Glipizide GITS in the Treatment of Type 2 Diabetes Mellitus[J];Chinese Journal of Evidence-Based Medicine;2004-07

  本文關(guān)鍵詞：地特胰島素注射液的臨床效果和經(jīng)濟(jì)學(xué)評價研究綜述，由筆耕文化傳播整理發(fā)布。