發(fā)布時(shí)間：2018-05-24 19:59

  本文選題：超表面 + 太赫茲生物傳感器��； 參考：《桂林電子科技大學(xué)》2017年碩士論文

【摘要】：太赫茲波光子能量遠(yuǎn)小于X射線的能量,不會(huì)對(duì)人體產(chǎn)生電離輻射、安全性好,因此,太赫茲技術(shù)在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用研究成為當(dāng)前的一個(gè)研究熱點(diǎn)。由于生物組織含水,水對(duì)太赫茲波的吸收很強(qiáng)烈,導(dǎo)致太赫茲波衰減十分嚴(yán)重,這成為太赫茲技術(shù)在生物醫(yī)學(xué)領(lǐng)域應(yīng)用的一大障礙。人工電磁材料(超材料)的出現(xiàn),特別是超表面的發(fā)展,對(duì)太赫茲技術(shù)在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用起到了極大的促進(jìn)作用。因?yàn)槌砻嬷谱鞯母哽`敏度太赫茲傳感器,對(duì)表面介電環(huán)境的變化十分敏感,可利用這一特性來(lái)表征和監(jiān)測(cè)藥物反應(yīng)的特征變化。本文主要開(kāi)展超表面太赫茲傳感器的太赫茲響應(yīng)特性及其在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用研究,具體研究?jī)?nèi)容如下:1.研究超表面太赫茲傳感器的理論、設(shè)計(jì)方法、加工方法和傳感特性。設(shè)計(jì)了歐姆環(huán)結(jié)構(gòu)、開(kāi)口環(huán)與一字形復(fù)合結(jié)構(gòu)兩種超表面太赫茲傳感器,并用表面微加工工藝制作出了樣片。2.研究超表面太赫茲傳感器用于蛋白質(zhì)與藥物反應(yīng)過(guò)程監(jiān)測(cè)。首先,選取羅紅霉素、頭孢拉定、諾氟沙星和環(huán)丙沙星四種藥物溶液與牛血清白蛋白溶液進(jìn)行反應(yīng),然后取微量反應(yīng)溶液滴到傳感器表面,用太赫茲時(shí)域光譜系統(tǒng)測(cè)定反應(yīng)溶液在不同時(shí)間的太赫茲時(shí)域透射光譜,根據(jù)傳感器諧振峰的頻移變化來(lái)表征反應(yīng)過(guò)程。研究表明,超表面太赫茲傳感器可用于監(jiān)測(cè)蛋白質(zhì)與藥物的反應(yīng)過(guò)程,為后續(xù)其它蛋白質(zhì)與藥物反應(yīng)的研究提供了一種新型、高效的方法。3.研究超表面太赫茲傳感器對(duì)不同抗生素類(lèi)藥物濃度的檢測(cè)。選取環(huán)丙沙星、羅紅霉素和諾氟沙星這三種常見(jiàn)抗生素進(jìn)行實(shí)驗(yàn),實(shí)驗(yàn)發(fā)現(xiàn)開(kāi)口環(huán)與一字形復(fù)合結(jié)構(gòu)的諧振峰頻移量與抗生素濃度大小近似成正比例關(guān)系。而且,開(kāi)口環(huán)與一字形復(fù)合結(jié)構(gòu)對(duì)不同抗生素濃度的敏感程度不完全一樣。因此,超表面太赫茲傳感器可以實(shí)現(xiàn)對(duì)不同抗生素類(lèi)藥物濃度的檢測(cè)。4.研究將超表面太赫茲生物傳感器用于抗癌藥與核酸反應(yīng)過(guò)程監(jiān)測(cè)。通過(guò)對(duì)秋水仙堿和甲氨蝶呤兩種抗癌藥與核酸的反應(yīng)過(guò)程進(jìn)行研究,證明了超表面太赫茲傳感器用于抗癌藥與核酸反應(yīng)過(guò)程監(jiān)測(cè)的可行性。這些研究成果,對(duì)處于攻關(guān)階段的抗癌藥及其藥效研究具有十分重要的意義。
[Abstract]:The energy of terahertz photons is much smaller than that of X-ray, and it will not produce ionizing radiation to human body. Therefore, the application of terahertz technology in biomedical field has become a hot research topic. Because of the water content in biological tissues, the absorption of terahertz wave by water is very strong, resulting in the attenuation of terahertz wave is very serious, which has become a major obstacle to the application of terahertz technology in biomedical field. The appearance of artificial electromagnetic materials (metamaterials), especially the development of supersurface, has greatly promoted the application of terahertz technology in biomedical field. The high sensitivity terahertz sensor is very sensitive to the change of the dielectric environment of the surface, which can be used to characterize and monitor the characteristic changes of the drug reaction. In this paper, the terahertz response of supersurface terahertz sensor and its application in biomedical field are studied. The research contents are as follows: 1. The theory, design method, processing method and sensing characteristics of supersurface terahertz sensor are studied. Two kinds of super-surface terahertz sensors were designed with ohmic ring structure, open ring and one zigzag composite structure. The supersurface terahertz sensor is used to monitor the reaction between protein and drugs. Firstly, roxithromycin, cefradine, norfloxacin and ciprofloxacin were selected to react with bovine serum albumin solution. Terahertz time-domain spectroscopy system was used to measure the THz time-domain transmission spectra of the reaction solution at different times. The reaction process was characterized by the frequency shift of the resonant peak of the sensor. The results show that the surface-THz sensor can be used to monitor the reaction process between protein and drug, which provides a new and efficient method for the further study of the reaction between other proteins and drugs. The determination of concentration of different antibiotics by surfaced terahertz sensor was studied. Three common antibiotics, ciprofloxacin, roxithromycin and norfloxacin, were selected for experiments. It was found that the resonant peak frequency shift of the open ring and a zigzag composite structure was approximately proportional to the concentration of antibiotics. Moreover, the sensitivity of the open ring and a zigzag composite structure to different antibiotic concentrations is not exactly the same. Therefore, the supersurface terahertz sensor can be used to detect the concentration of different antibiotics. The supersurface terahertz biosensor was used to monitor the reaction of anticancer drugs with nucleic acid. By studying the reaction process of colchicine and methotrexate with nucleic acid, it is proved that the supersurface terahertz sensor can be used to monitor the reaction process between anticancer drug and nucleic acid. These results are of great significance to the study of anticancer drugs and their efficacy at the critical stage.
【學(xué)位授予單位】：桂林電子科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：TP212

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