發(fā)布時(shí)間：2019-01-08 09:26

【摘要】：在采用近紅外漫反射光譜對(duì)渾濁介質(zhì)中的物質(zhì)濃度做定量分析時(shí),物質(zhì)濃度測(cè)量的靈敏度與所選的光源-檢測(cè)器位置有較大的關(guān)聯(lián)。解析了物質(zhì)濃度測(cè)量的靈敏度隨光源-檢測(cè)器距離變化的曲線特點(diǎn),給出了三個(gè)特殊位置:靈敏度全局極大位置、靈敏度為零的位置和靈敏度局部極大的位置。以葡萄糖在某渾濁介質(zhì)溶液(含血紅蛋白、白蛋白的Intralipid溶液)中的測(cè)量為例,從擴(kuò)散方程、蒙特卡羅模擬、漫反射光譜測(cè)量實(shí)驗(yàn)三方面,均驗(yàn)證了靈敏度曲線中存在的這三個(gè)特殊位置。另一方面,考慮到近紅外光源的穩(wěn)定性、銦鎵砷檢測(cè)器的量子效率與系統(tǒng)噪聲等因素的限制,采用儀器的信噪比作為另一個(gè)客觀指標(biāo),對(duì)實(shí)際測(cè)量可得到的靈敏度進(jìn)行了評(píng)價(jià)。綜合靈敏度曲線的特點(diǎn)和儀器的實(shí)際測(cè)量水平,給出了測(cè)量葡萄糖的最佳位置,可實(shí)現(xiàn)最優(yōu)的測(cè)量靈敏度與測(cè)量精度。采用優(yōu)化后的測(cè)量位置,葡萄糖的測(cè)量靈敏度可提高10倍以上。測(cè)量葡萄糖靈敏度的研究對(duì)人體組織中的無(wú)創(chuàng)血糖檢測(cè)有較好的參考價(jià)值,同時(shí),對(duì)漫射光譜靈敏度的解析方法可被借鑒于其他物質(zhì)的近紅外漫反射光譜測(cè)量位置的優(yōu)選。
[Abstract]:In the quantitative analysis of the mass concentration in turbid media by near infrared diffuse reflectance spectroscopy, the sensitivity of the material concentration measurement is closely related to the position of the selected light source and detector. In this paper, the characteristics of the curve of the sensitivity of the material concentration measurement with the distance between the light source and the detector are analyzed, and three special positions are given: the global maximum position of sensitivity, the position of zero sensitivity and the position of local maximum sensitivity. Taking the measurement of glucose in a turbid medium solution (Intralipid solution containing hemoglobin and albumin) as an example, the diffusion equation, Monte Carlo simulation and diffuse reflectance spectrum measurement experiments were studied. These three special positions in the sensitivity curve are verified. On the other hand, considering the stability of near infrared light source, quantum efficiency of indium gallium arsenic detector and system noise, the SNR of the instrument is used as another objective index to evaluate the sensitivity obtained from the actual measurement. Based on the characteristics of the sensitivity curve and the actual measurement level of the instrument, the optimum position of glucose measurement is given, which can achieve the optimal measurement sensitivity and accuracy. The sensitivity of glucose measurement can be increased by more than 10 times by using the optimized measuring position. The study of glucose sensitivity has a good reference value for noninvasive blood glucose detection in human tissues. At the same time, the analytical method of diffuse spectral sensitivity can be used for reference to select the location of other substances in near-infrared diffuse reflectance spectroscopy measurement.
【作者單位】： 天津大學(xué)精密測(cè)試技術(shù)及儀器國(guó)家重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家863計(jì)劃(2012AA022602,2012YQ090194) 國(guó)家自然科學(xué)基金(60938002,81471698)
【分類號(hào)】：O433.1

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