【摘要】：目的:通過搜集在中國(guó)期刊網(wǎng)全文數(shù)據(jù)庫公開發(fā)表的關(guān)于慢性乙型病毒性肝炎的相關(guān)文章,采用IBM SPSS20.0數(shù)據(jù)挖掘軟件作為挖掘工具,探索慢性乙型病毒性肝炎的用藥規(guī)律。方法:以設(shè)定好的關(guān)鍵詞為檢索條件收集中國(guó)期刊網(wǎng)全文數(shù)據(jù)庫(CNKI)中公開發(fā)表的治療慢性乙型病毒性肝炎的相關(guān)文獻(xiàn),依據(jù)納入標(biāo)準(zhǔn)與排除標(biāo)準(zhǔn),建立方劑數(shù)據(jù)庫,對(duì)方劑中的中藥規(guī)范化處理后,建立中藥原始數(shù)據(jù)庫,運(yùn)用IBM SPSS20.0軟件進(jìn)行數(shù)據(jù)挖掘,總結(jié)藥物的四性、五味、歸經(jīng)、用藥頻次的規(guī)律,方劑涉及的證候分布規(guī)律,聚類分析得到新的高頻藥物組合。結(jié)果:四性統(tǒng)計(jì)中居于第一位的是“寒”,五味統(tǒng)計(jì)中居于第一位的是“苦”,歸經(jīng)統(tǒng)計(jì)中居于第一位的是“肝經(jīng)”,方劑證候統(tǒng)計(jì)中居于第一位的是“肝郁脾虛證”,高頻藥物的歸類中前兩位是清熱類與補(bǔ)虛類中藥,聚類分析挖掘藥物組合(2味中藥)10個(gè)、高頻藥物組合(2味中藥)6個(gè)。結(jié)論:運(yùn)用數(shù)據(jù)挖掘技術(shù)探索慢性乙型肝炎的中醫(yī)藥治療用藥的基本規(guī)律:現(xiàn)代中醫(yī)藥治療慢性乙型病毒性肝炎的藥物的使用四性與五味以苦寒、甘溫類中藥為主;藥物歸經(jīng)以肝經(jīng)、脾經(jīng)、胃經(jīng)、腎經(jīng)為主,說明慢乙肝的治療主要以三臟為主,可以反推出慢乙肝的病變部位主要在于肝臟;涉及中藥方劑的證候以肝郁脾虛、瘀血阻絡(luò)等虛實(shí)夾雜病證為主;藥物的使用頻次歸類,以清熱類與補(bǔ)虛類為多;聚類分析得到高頻藥物組合若干,這些高頻藥物組合能夠針對(duì)慢乙肝的主要致病因子“濕、熱、毒、痰、虛、瘀”等起到特定的治療作用,為臨床慢性乙型肝炎的辨證治療提供辨證思路及組方思維,為新藥的研發(fā)提供參考。
[Abstract]:Objective: to explore the rule of drug use of chronic viral hepatitis B by using IBM SPSS 20.0 data mining software through collecting related articles published in the full text database of Chinese Journal Network. Methods: according to the criteria of inclusion and exclusion, the Chinese Journal Network Full-text Database (CNKI) was used to collect the literature on the treatment of chronic viral hepatitis B (CHB), and the database of prescriptions was established according to the criteria of inclusion and exclusion. After standardized treatment of traditional Chinese medicine in prescription, the original database of traditional Chinese medicine was established, and the data mining was carried out by using IBM SPSS 20.0 software. The four properties, five flavors, return to the classics, the regularity of the frequency of medication, and the distribution law of syndromes involved in the prescription were summarized. A new high-frequency drug combination was obtained by cluster analysis. Results: among the four sex statistics, the "cold" is the first, the "bitter" is the first in the five-flavor statistics, the "liver classics" is the first in the statistics of returning to the classics, and the first in the syndrome statistics of prescription is "liver depression and spleen deficiency syndrome". In the classification of high frequency drugs, the first two are clearing heat and tonifying deficiency. Cluster analysis excavates 10 drug combinations (2 Chinese medicines) and 6 high frequency drugs combinations (2 kinds of traditional Chinese medicines). Conclusion: using data mining technology to explore the basic law of traditional Chinese medicine in treating chronic hepatitis B: the four and five kinds of drugs used in the treatment of chronic hepatitis B are mainly bitter cold and sweet and warm Chinese medicine. The main drugs are liver Meridian, spleen Meridian, stomach Meridian and Kidney Meridian, indicating that the treatment of chronic Hepatitis B mainly consists of three viscera, and the pathological position of CHB can be inferred mainly from the liver; the syndromes related to traditional Chinese medicine prescription are liver stagnation and spleen deficiency. Blood stasis and blockage of collaterals and so on are the main types of diseases with deficiency and deficiency; the use frequency of drugs is classified into the categories of clearing heat and tonifying deficiency; cluster analysis shows several combinations of high frequency drugs, which can be aimed at the main pathogenic factors of chronic hepatitis B, namely, wetness, heat, etc. Poison, phlegm, deficiency and stasis "play a special role in treating chronic hepatitis B, and provide dialectical thinking and prescription thinking for clinical treatment of chronic hepatitis B, and provide reference for the research and development of new drugs."
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259;TP311.13

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