沙門菌減毒疫苗候選基因的研究進(jìn)展
發(fā)布時(shí)間:2019-03-27 11:52
【摘要】:減毒沙門菌活疫苗比滅活疫苗和亞單位疫苗優(yōu)越,不僅能誘導(dǎo)強(qiáng)烈的體液免疫反應(yīng)、黏膜免疫反應(yīng)和細(xì)胞免疫反應(yīng),還可用作疫苗載體。利用現(xiàn)代基因工程技術(shù)構(gòu)建減毒沙門菌活疫苗需要平衡減毒沙門菌毒力及其免疫原性,因此其候選基因的選擇至關(guān)重要。文章概括地闡述了沙門菌減毒疫苗候選基因的研究進(jìn)展,為將來新疫苗的研究提供參考。
[Abstract]:Live attenuated Salmonella vaccine is superior to inactivated vaccine and subunit vaccine. It not only can induce strong humoral immune response, mucosal immune response and cellular immune response, but also can be used as vaccine carrier. It is necessary to balance the virulence and immunogenicity of attenuated Salmonella to construct live attenuated Salmonella vaccine by modern genetic engineering technology, so the selection of candidate genes is very important. In this paper, the research progress of candidate genes for attenuated Salmonella vaccine is summarized, which provides reference for the future research of new vaccines.
【作者單位】: 揚(yáng)州大學(xué)農(nóng)業(yè)部農(nóng)產(chǎn)品質(zhì)量安全生物性危害因子(動(dòng)物源)控制重點(diǎn)實(shí)驗(yàn)室江蘇省人獸共患病學(xué)重點(diǎn)實(shí)驗(yàn)室;江蘇省動(dòng)物重要疫病與人獸共患病防控協(xié)同創(chuàng)新中心;
【基金】:國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2016YFD0501607) 公益性行業(yè)(農(nóng)業(yè))科研專項(xiàng)(201403054) 江蘇省自然科學(xué)基金項(xiàng)目(BK20151306) 揚(yáng)州大學(xué)科技創(chuàng)新團(tuán)隊(duì)建設(shè)
【分類號(hào)】:S852.4
[Abstract]:Live attenuated Salmonella vaccine is superior to inactivated vaccine and subunit vaccine. It not only can induce strong humoral immune response, mucosal immune response and cellular immune response, but also can be used as vaccine carrier. It is necessary to balance the virulence and immunogenicity of attenuated Salmonella to construct live attenuated Salmonella vaccine by modern genetic engineering technology, so the selection of candidate genes is very important. In this paper, the research progress of candidate genes for attenuated Salmonella vaccine is summarized, which provides reference for the future research of new vaccines.
【作者單位】: 揚(yáng)州大學(xué)農(nóng)業(yè)部農(nóng)產(chǎn)品質(zhì)量安全生物性危害因子(動(dòng)物源)控制重點(diǎn)實(shí)驗(yàn)室江蘇省人獸共患病學(xué)重點(diǎn)實(shí)驗(yàn)室;江蘇省動(dòng)物重要疫病與人獸共患病防控協(xié)同創(chuàng)新中心;
【基金】:國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2016YFD0501607) 公益性行業(yè)(農(nóng)業(yè))科研專項(xiàng)(201403054) 江蘇省自然科學(xué)基金項(xiàng)目(BK20151306) 揚(yáng)州大學(xué)科技創(chuàng)新團(tuán)隊(duì)建設(shè)
【分類號(hào)】:S852.4
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