珠江口3種鯨豚的MHC-I基因多態(tài)性研究
發(fā)布時間：2018-09-13 07:50
【摘要】：旨在了解珠江口棲息的中華白海豚(Sousa chinensis)、寬脊江豚(Neophocaena phocaenoides)和點斑原海豚(Stenella attenuate)免疫相關(guān)基因MHC-I(Major Histocompatibility Complex)的多態(tài)性及其表達情況,以期為這3種鯨豚的保育工作提供基礎(chǔ)資料。通過克隆測序的方法,首次證實MHC-I基因在這3種鯨豚體內(nèi)表達。選擇壓力分析,表明MHC-I基因在這3種鯨豚中均受到強烈的正選擇作用,提示其具有重要的免疫功能。3種鯨豚的MHC-I基因在系統(tǒng)發(fā)育樹上相互混雜在一起,表明MHC-I基因存在跨物種多態(tài)性。結(jié)合選擇壓力分析和跨物種多態(tài)性,發(fā)現(xiàn)MHC-I基因受到平衡選擇作用。珠江口3種鯨豚MHC-I基因多態(tài)性可能由平衡選擇維持。
[Abstract]:The aim of this study was to investigate the polymorphisms and expression of the immune-related genes MHC-I (Major Histocompatibility Complex) in the Chinese white dolphins (Sousa chinensis), Neophocaena phocaenoides and Stenella attenuate inhabiting the Pearl River Estuary, and to provide basic information for the conservation of the three species of cetaceans. Sequence analysis showed that MHC-I gene was strongly positive in all three species of cetaceans, suggesting that MHC-I gene had important immune function. Mixed MHC-I genes were found in phylogenetic trees of three species of cetaceans, suggesting that MHC-I gene was polymorphic across species. Combining selection stress analysis and cross-species polymorphism, we found that MHC-I gene was affected by balanced selection. The MHC-I gene polymorphism of three species of whales in the Pearl River Estuary may be maintained by balanced selection.
【作者單位】： 南海生物資源開發(fā)與利用協(xié)同創(chuàng)新中心;廣東省海洋資源與近岸工程重點實驗室;珠海市海洋生物資源與環(huán)境重點實驗室;中山大學(xué)海洋科學(xué)學(xué)院;
【基金】：國家自然科學(xué)基金項目(41276147,41576128) 農(nóng)業(yè)部中華白海豚保護行動計劃(2015); 香港海洋公園保育基金(2013)~~
【分類號】：Q953
本文編號：2240524
[Abstract]:The aim of this study was to investigate the polymorphisms and expression of the immune-related genes MHC-I (Major Histocompatibility Complex) in the Chinese white dolphins (Sousa chinensis), Neophocaena phocaenoides and Stenella attenuate inhabiting the Pearl River Estuary, and to provide basic information for the conservation of the three species of cetaceans. Sequence analysis showed that MHC-I gene was strongly positive in all three species of cetaceans, suggesting that MHC-I gene had important immune function. Mixed MHC-I genes were found in phylogenetic trees of three species of cetaceans, suggesting that MHC-I gene was polymorphic across species. Combining selection stress analysis and cross-species polymorphism, we found that MHC-I gene was affected by balanced selection. The MHC-I gene polymorphism of three species of whales in the Pearl River Estuary may be maintained by balanced selection.
【作者單位】： 南海生物資源開發(fā)與利用協(xié)同創(chuàng)新中心;廣東省海洋資源與近岸工程重點實驗室;珠海市海洋生物資源與環(huán)境重點實驗室;中山大學(xué)海洋科學(xué)學(xué)院;
【基金】：國家自然科學(xué)基金項目(41276147,41576128) 農(nóng)業(yè)部中華白海豚保護行動計劃(2015); 香港海洋公園保育基金(2013)~~
【分類號】：Q953
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