發(fā)布時(shí)間：2018-07-03 07:18

  本文選題：心肌梗死 + 凝血因子Ⅻ　； 參考：《浙江醫(yī)學(xué)》2016年23期

【摘要】：目的分析急性心肌梗死(AMI)患者凝血因子Ⅻ(FⅫ)基因多態(tài)性和急性發(fā)作時(shí)血漿凝血因子Ⅻ活性(FⅫ:C)的變化及意義。方法收集97例AMI患者治療前及76例對(duì)照血液標(biāo)本,采用直接測(cè)序法檢測(cè)FⅫ第46位基因多態(tài)性和一期凝固法檢測(cè)血漿FⅫ:C,并進(jìn)行比較分析。結(jié)果 FⅫ基因C46T多態(tài)位點(diǎn)CC、CT、TT 3種基因型以及C、T等位基因頻率在AMI組與對(duì)照組中的分布均無(wú)統(tǒng)計(jì)學(xué)差異(均P0.05)。CC、CT和TT 3種基因型分別對(duì)應(yīng)的血漿FⅫ:C水平有統(tǒng)計(jì)學(xué)差異(P0.01),以CC組活性最高,TT組活性最低。AMI組血漿FⅫ:C顯著低于對(duì)照組(P0.01)。結(jié)論 FⅫC46T基因多態(tài)性與AMI無(wú)關(guān)聯(lián),AMI發(fā)病時(shí)血漿FⅫ:C顯著降低,FⅫ參與血栓形成。
[Abstract]:Objective to analyze the variation and significance of the gene polymorphisms of clotting factor (F) and the activity of plasma coagulation factor (F?) in patients with acute myocardial infarction (AMI) during acute exacerbation of acute myocardial infarction (AMI). Methods 97 patients with AMI and 76 control blood samples were collected. The 46th position polymorphism of F _ (XII) gene was detected by direct sequencing method, and the plasma F _ (鈪，

本文編號(hào)：2092868