本文選題：包蟲病 + HLA-DRB�。� 參考：《中國血吸蟲病防治雜志》2017年05期

【摘要】：目的確定青藏高原地區(qū)藏族人群包蟲病患者的人類白細胞抗原-DRB1(Human leukocyte antigen-DRB1,HLADRB1)等位基因中易感基因和抗性基因,為研究藏族人群包蟲病的感染機制及遺傳特點提供依據(jù)。方法本研究采用病例對照法。病例組選取青海省玉樹和果洛藏族自治州的世居藏族囊型包蟲病63例和泡型包蟲病73例;對照組選取該地區(qū)無血緣關系的藏族健康人,共計60例。應用聚合酶鏈反應-直接堿基序列基因分型(PCR-SBT)技術,比較等位基因頻率。結果泡型和囊型包蟲病病例組HLA-DRB1*04等位基因頻率均小于對照組(χ2=4.71、4.31,P均0.05)。結論HLA-DRB1*04等位基因與青藏高原藏族人群囊型和泡型包蟲病相關聯(lián),對其感染有保護作用,是其抗性基因。
[Abstract]:Objective to identify susceptibility genes and resistance genes of human leukocyte antigen-DRB1 HLA-DRB1 alleles in patients with hydatid disease in Tibetan population in Qinghai-Tibet Plateau, and to provide evidence for studying the infection mechanism and genetic characteristics of hydatid disease in Tibetan population. Methods the case-control method was used in this study. 63 cases of Tibetan cystic echinococcosis and 73 cases of alveolar hydatidosis in Yushu and Guoluo Tibetan Autonomous Prefecture of Qinghai Province were selected in the case group, while 60 healthy Tibetan people in the control group were selected as control group. Polymerase chain reaction-direct base sequence genotyping (PCR-SBT) technique was used to compare allelic frequencies. Results the frequency of HLA-DRB1*04 alleles in patients with vesicular hydatid disease and cystic hydatid disease was lower than that in control group (蠂 ~ 2 = 4.71 ~ 4.31, P = 0.05). Conclusion HLA-DRB1*04 allele is associated with cystic and alveolar hydatid disease in Tibetan population of Qinghai-Xizang Plateau. It has protective effect on infection and is a resistant gene.
【作者單位】： 青海省人民醫(yī)院;青海省地方病預防控制所;中國人民解放軍第四醫(yī)院;
【基金】：青海省科技廳資助項目(2015.ZJ.750)
【分類號】：R532.32
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本文編號：1986267