本文選題：TYR基因 + 酪氨酸酶相關蛋白家族�。� 參考：《中國畜牧雜志》2017年04期

【摘要】：TYR基因是酪氨酸酶相關蛋白家族(Tyrosinase-related Protein)成員之一,酪氨酸酶是黑色素合成過程中的限速酶,TYR表達量及活性的高低直接影響真黑素與褐黑素的表達,進而對動物毛色產(chǎn)生影響。為深入了解TYR基因結構功能、多態(tài)性及TYR基因表達量與毛皮動物毛色的相關性,本文在查閱大量文獻基礎上,對TYR基因結構與功能以及在臨床醫(yī)學、畜牧生產(chǎn)上的應用研究等方面進行綜述。通過綜述大量文獻發(fā)現(xiàn),TYR基因突變不僅與人類皮膚白化病有明顯關系,對哺乳動物被毛白化現(xiàn)象也有明顯關系,而且在深色被毛哺乳動物中的表達量普遍高于淺色被毛哺乳動物。
[Abstract]:TYR gene is a member of tyrosinase-related protein family, tyrosinase-related protein. Tyrosinase is a rate-limiting enzyme in melanin synthesis. In order to understand the relationship between the structure and function of TYR gene, polymorphism, TYR gene expression and fur animal fur color, the structure and function of TYR gene and clinical medicine were studied in this paper. The application research of animal husbandry production is reviewed. By reviewing a large number of literatures, we find that the mutation of TYR gene is not only related to human skin albinism, but also to the albinism of mammalian hair. Moreover, the expression level in dark hairy mammals is generally higher than that in light-colored hairy mammals.
【作者單位】： 貴州大學高原山地動物遺傳育種與繁殖省部共建教育部重點實驗室;貴州大學動物科學學院貴州省動物遺傳與繁殖重點實驗室;
【基金】：貴州省科技富民強縣專項行動計劃([2014]5202-1) 貴州省科技廳2013年省市縣科技合作項目(2013001)
【分類號】：S852.2
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本文編號：1978710