本文選題：非霍奇金淋巴瘤 + 甲氨蝶呤�。� 參考：《中國臨床藥理學雜志》2016年21期

【摘要】：目的考察葉酰多聚谷氨酸合成酶(FPGS)rsl544105和γ-谷氨酰水解酶(GGH)rs3758149基因多態(tài)性與甲氨蝶呤(MTX)治療非霍奇金淋巴瘤(NHL)所致藥物不良反應的相關性。方法收集81例使用大劑量MTX化療的NHL患者血樣,用直接測序法檢測FPGS rsl544105和GGH rs3758149基因多態(tài)性。用美國國立癌癥中心通用藥物不良反應術語標準統(tǒng)一評價MTX化療后的藥物不良反應。用SPPS軟件分析FPGS rsl544105和GGH rs3758149基因多態(tài)性與MTX藥物不良反應的相關性。結果 FPGS rsl544105位點GG、GA和AA基因的分布頻率分別為6.17%,39.51%和54.32%,G和A等位基因的分布頻率為25.93%和74.07%。GGH rs3758149位點CC、CT和TT基因的分布頻率分別為65.43%,33.33%和1.23%,C和T等位基因的分布頻率為82.10%和17.90%。FPGS rs1544105野生型(GG)和突變型(GA+AA)患者發(fā)生2級以上骨髓毒性和肝毒性的比例之間差異無統(tǒng)計學意義(P0.05)。GGH rs3758149野生型(CC)和突變型(CT+TT)患者發(fā)生2級以上中性粒細胞減少的比例分別為35.85%和10.71%,差異有統(tǒng)計學意義(P0.05)。結論 FPGS rsl544105可能與NHL患者MTX化療后2級以上骨髓毒性和肝毒性發(fā)生率無相關性;而GGH rs3758149基因多態(tài)性與NHL患者MTX化療后2級以上中性粒細胞減少發(fā)生率存在相關性。
[Abstract]:Objective to investigate the relationship between polymorphisms of FPGSN rsl544105 and gamma-glutamyl hydrolase GGHrs3758149 and adverse drug reactions induced by methotrexate (MTX) in the treatment of non-Hodgkin 's lymphoma. Methods Blood samples were collected from 81 patients with NHL who received high dose MTX chemotherapy. FPGS rsl544105 and GGH rs3758149 gene polymorphisms were detected by direct sequencing. Adverse drug reactions after MTX chemotherapy were evaluated uniformly using the National Cancer Center General adverse Drug reaction terminology. SPPS software was used to analyze the relationship between FPGS rsl544105 and GGH rs3758149 gene polymorphisms and adverse drug reactions in MTX. Results the frequencies of GGG GG and AA at FPGS rsl544105 locus were 6.179.51% and 54.32%, respectively. The frequencies of G and A alleles were 25.93% and 65.43 ~ 33.33% and 1.23C and T alleles were 82.10% and 65.43 ~ 33.33%, respectively. There was no significant difference in the proportion of grade 2 or more of bone marrow toxicity and hepatotoxicity between patients with 17.90%.FPGS rs1544105 wild type GG) and mutant GA-AAA. There was no significant difference in the incidence of grade 2 or more neutropenia in patients with 17.90%.FPGS rs1544105 wild type or GGH rs3758149. The ratio was 35.85% and 10.71% respectively, the difference was statistically significant (P 0.05). Conclusion FPGS rsl544105 may not be associated with the incidence of bone marrow toxicity and hepatotoxicity in patients with NHL above grade 2 after MTX chemotherapy, while the polymorphism of GGH rs3758149 gene is associated with the incidence of neutropenia above grade 2 after MTX chemotherapy in NHL patients.
【作者單位】： 福建省腫瘤醫(yī)院/福建醫(yī)科大學附屬腫瘤醫(yī)院藥劑科;
【基金】：國家臨床重點�？平ㄔO基金資助項目(2013) 福建省自然科學基金資助項目(2016J01509) 福建省衛(wèi)生廳青年科研課題基金資助項目(2013-1-8)
【分類號】：R733.1

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