本文選題：白細(xì)胞介素- + 多態(tài)性��； 參考：《重慶醫(yī)學(xué)》2017年15期

【摘要】：目的系統(tǒng)評(píng)價(jià)白細(xì)胞介素-6(IL-6)基因-572C/G(rs1800796)多態(tài)性與小兒熱性驚厥易感性的關(guān)系。方法計(jì)算機(jī)檢索PubMed,Web of Science,Embase,Cochrane Library,中國(guó)知網(wǎng)(CNKI),萬(wàn)方,維普(VIP)及中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM),收集發(fā)表的IL-6基因rs1800796多態(tài)性與小兒熱性驚厥易感性的相關(guān)文獻(xiàn),以O(shè)R及其95%CI為合并效應(yīng)量,采用RevMan 5.2軟件進(jìn)行統(tǒng)計(jì)學(xué)分析,以STATA12.0軟件進(jìn)行發(fā)表偏倚分析。結(jié)果根據(jù)納入及排除標(biāo)準(zhǔn),本研究共納入7項(xiàng)獨(dú)立的病例-對(duì)照研究,累計(jì)病例516例,對(duì)照528例。結(jié)果顯示IL-6基因-572C/G(rs1800796)多態(tài)性與小兒熱性驚厥易感性之間具有顯著關(guān)聯(lián)(GG+CGvs.CC:OR=2.22,P=0.05;Gvs.C:OR=2.44,P0.01;GGvs.CC:OR=3.69,P=0.03;GGvs.CG+CC:OR=3.43,P0.01)。根據(jù)可能的重要的混雜因素進(jìn)行亞組分析,結(jié)果顯示,在中國(guó)人群中,該基因多態(tài)性與小兒熱性驚厥發(fā)病風(fēng)險(xiǎn)具有顯著關(guān)聯(lián)(GG+CGvs.CC:OR=3.32,P0.01;Gvs.C:OR=3.23,P0.01;GGvs.CC:OR=7.27,P0.01;GG vs.CG+CC:OR=5.17,P0.01:CGvs.CC:OR=2.56,P=0.02)。而在其他人群中除在隱形模型(GGvs.CG+CC:OR=2.40,P0.01)外,其他遺傳模型均未顯示明顯相關(guān)性。根據(jù)FS診斷標(biāo)準(zhǔn)進(jìn)行亞組分析,結(jié)果發(fā)現(xiàn),依據(jù)中國(guó)標(biāo)準(zhǔn)進(jìn)行診斷時(shí),該基因多態(tài)性與小兒熱性驚厥發(fā)病具有顯著相關(guān)性(GG+CGvs.CC:OR=4.57,P0.01;Gvs.C:OR=4.36,P0.01;GG vs.CC:OR=12.75,P0.01;GG vs.CG+CC:OR=8.60,P0.01:CG vs.CC:OR=3.40,P0.01)。結(jié)論IL-6基因-572C/G(rs1800796)多態(tài)性可能與小兒FS易感性有關(guān),G等位基因可能是FS發(fā)病的危險(xiǎn)因子。
[Abstract]:Objective to systematically evaluate the relationship between the polymorphism of interleukin -6 (IL-6) gene -572C/G (rs1800796) and the susceptibility to febrile convulsion in children. Methods a computer was used to retrieve PubMed, Web of Science, Embase, Cochrane Library, Chinese know net (CNKI), Wanfang, VP and Chinese biomedical literature database. The related literature of the susceptibility to febrile convulsion in children, using OR and its 95%CI as the combined effect, using RevMan 5.2 software for statistical analysis, and using STATA12.0 software for publication bias analysis. Results according to the inclusion and exclusion criteria, this study included 7 independent case control studies, 516 cases of cumulative cases, and 528 cases of control. There was a significant association between the IL-6 gene -572C/G (rs1800796) polymorphism and the susceptibility to febrile convulsion in children (GG+CGvs.CC:OR=2.22, P=0.05; Gvs.C:OR=2.44, P0.01; GGvs.CC:OR=3.69, P=0.03; GGvs.CG+CC:OR=3.43, P0.01). Subgroup analysis based on possible major confounding factors showed that the gene polymorphism was found in Chinese population. There is a significant association with the risk of febrile convulsion in children (GG+CGvs.CC:OR=3.32, P0.01; Gvs.C:OR=3.23, P0.01; GGvs.CC:OR=7.27, P0.01; GG vs.CG+CC:OR=5.17, P0.01:CGvs.CC:OR=2.56, P=0.02). But in other populations, except for the stealth model (GGvs.CG+CC:OR=2.40, P0.01), other genetic models have not shown significant correlation. The subgroup analysis showed that there was a significant correlation between the polymorphism of the gene and the onset of febrile convulsion in children (GG+CGvs.CC:OR=4.57, P0.01; Gvs.C:OR=4.36, P0.01; GG vs.CC:OR=12.75, P0.01; GG vs.CG+CC:OR=8.60, P0.01:CG vs.CC:OR=3.40). Sex may be associated with susceptibility to FS in children, and G allele may be a risk factor for FS.

【作者單位】： 湖北省十堰市婦幼保健院兒童保健中心;
【分類號(hào)】：R720.597

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本文編號(hào)：1856501