本文選題：肺腫瘤 + 非小細胞肺癌　； 參考：《山東醫(yī)藥》2017年38期

【摘要】：目的觀察成纖維生長因子受體1(FGFR1)基因在非小細胞肺癌(NSCLC)組織中的擴增情況,并探討其與臨床病理特征的關系。方法 147例NSCLC患者,經無痛纖維支氣管鏡檢查或經皮肺穿刺檢查時取得腫瘤組織。采用熒光原位雜交(FISH)技術觀察組織中FGFR1基因擴增情況,采用χ2檢驗或Fisher's確切概率法分析FGFR1基因擴增與NSCLC患者臨床病理特征的關系。結果 147例NSCLC腫瘤組織中FGFR1基因擴增11例。44例鱗癌組織中FGFR1基因擴增7例,74例腺癌組織中FGFR1基因擴增4例,鱗癌與腺癌組織中FGFR1基因擴增情況比較P0.05。73例有吸煙史患者組織中FGFR1基因擴增11例,74例無吸煙史患者組織中FGFR1基因擴增0例,兩者相比P0.05。結論 FGFR1基因在NSCLC組織中存在擴增,且有吸煙史較無吸煙史患者擴增比例高,鱗癌較腺癌患者擴增比例高。
[Abstract]:Objective to investigate the amplification of fibroblast growth factor receptor (FGFR1) gene in non small cell lung cancer (NSCLC) and its relationship with clinicopathological features. Methods tumor tissues were obtained from 147 patients with NSCLC by painless fiberoptic bronchoscopy or percutaneous lung puncture. The amplification of FGFR1 gene in tissues was observed by fluorescence in situ hybridization (fish) technique. The relationship between the amplification of FGFR1 gene and the clinicopathological characteristics of NSCLC patients was analyzed by 蠂 2 test or Fisher's exact probability method. Results FGFR1 gene amplification was performed in 11 cases of NSCLC tumor tissues and 44 cases of squamous cell carcinoma tissues. FGFR1 gene amplification was performed in 7 cases of 74 cases of adenocarcinoma and 4 cases of FGFR1 gene amplification. Comparison of FGFR1 Gene Amplification in squamous Cell carcinoma and Adenocarcinoma; FGFR1 gene amplification was performed in 11 patients with smoking history and 0 patients with no smoking history, compared with P0.055.73 patients with smoking history. Conclusion FGFR1 gene was amplified in NSCLC tissue, and the proportion of FGFR1 gene amplification was higher in patients with smoking history than in patients with no smoking history, and the amplification rate of squamous cell carcinoma was higher than that of adenocarcinoma.
【作者單位】： 山東省醫(yī)學科學院附屬濟寧市第一人民醫(yī)院;濟南大學山東省醫(yī)學科學院醫(yī)學與生命科學學院;
【基金】：山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃項目(2013WS0056)
【分類號】：R734.2

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