本文選題：乳腺癌 + 卵巢癌�。� 參考：《山東醫(yī)藥》2017年35期

【摘要】：目的探討乳腺癌、卵巢癌組織NPR1基因表達變化與乳腺癌、卵巢癌預后的關系。方法用Oncomine數(shù)據(jù)庫分析乳腺癌組織、卵巢癌組織和正常組織中NPR1基因表達的差異,用Kaplan-Meier Plotter數(shù)據(jù)庫進行乳腺癌、卵巢癌患者生存分析,分析乳腺癌、卵巢癌組織NPR1基因表達變化與乳腺癌、卵巢癌預后的關系。結果 Oncomine數(shù)據(jù)庫包含了715個數(shù)據(jù)集和86 733個樣本。大數(shù)據(jù)分析結果顯示正常乳腺組織中NPR1基因高表達,乳腺癌組織中NPR1基因低表達。正常卵巢組織中NPR1基因低表達,卵巢癌組織中NPR1基因高表達。KaplanMeier Plotter數(shù)據(jù)庫包含了54 675個基因和10 461個癌癥樣本信息,其中包含5 143個乳腺癌患者樣本,1 861個卵巢癌患者樣本。大數(shù)據(jù)分析結果顯示乳腺癌組織NPR1基因高表達的患者無病生存時間較長(P0.05)�；讟有腿橄侔⑾偾籅型乳腺癌和HER2過表達型乳腺癌NPR1基因低表達和高表達患者預后無明顯差異(P均0.05);腺腔A型乳腺癌患者NPR1高表達預后明顯好于低表達者(P0.05)。卵巢癌組織NPR1基因低表達者的無進展生存時間比高表達者長(P0.05)。具體細分,漿液性卵巢癌和子宮內膜性卵巢癌組織NPR1基因低表達者的預后明顯好于高表達者(P均0.05)。結論乳腺癌組織NPR1基因高表達提示預后良好,而卵巢癌組織NPR1基因高表達提示預后不良。
[Abstract]:Objective to investigate the relationship between the expression of NPR1 gene and prognosis of breast cancer and ovarian cancer. Methods Oncomine database was used to analyze the difference of NPR1 gene expression in breast cancer, ovarian cancer and normal tissues. Kaplan-Meier Plotter database was used to analyze the survival of patients with breast cancer and ovarian cancer. Relationship between expression of NPR1 gene and prognosis of breast cancer and ovarian cancer. Results the Oncomine database contained 715 data sets and 86,733 samples. Big data analysis showed that NPR1 gene was highly expressed in normal breast tissue and NPR1 gene was low in breast cancer tissue. The overexpression of NPR1 gene in normal ovarian tissues. Kaplan Meier Plotter database contained 54 675 genes and 10 461 cancer samples, including 5 143 breast cancer samples and 1 861 ovarian cancer samples. Big data analysis showed that patients with high expression of NPR1 gene had a longer disease-free survival time (P 0.05). There was no significant difference in the prognosis of patients with low expression and high expression of NPR1 gene in basal type B breast cancer and HER2 overexpression type B breast cancer (P 0.05), and the prognosis of NPR1 high expression in type A breast cancer was significantly better than that in low expression group (P 0.05). The progression-free survival time of patients with low expression of NPR1 gene was longer than that of patients with high expression of NPR1 gene. The prognosis of patients with low expression of NPR1 gene in serous ovarian cancer and endometrial ovarian carcinoma was significantly better than that in those with high expression (P 0.05). Conclusion the high expression of NPR1 gene in breast cancer may indicate a good prognosis, while the high expression of NPR1 gene in ovarian cancer may suggest a poor prognosis.
【作者單位】： 中國醫(yī)科大學藥學院藥理教研室遼寧省分子靶向抗腫瘤藥物藥理學研究與評價重點實驗室;
【基金】：遼寧省高校創(chuàng)新團隊計劃資助項目(LT2014016) 遼寧省科技計劃項目(2014226033) 遼寧省高等學校優(yōu)秀人才支持計劃項目(LJQ2015118) 沈陽市科技計劃項目(F16-094-1-00);沈陽市科技計劃項目(17-123-9-00)
【分類號】：R737.31;R737.9
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本文編號：1799307