本文選題：腎素-血管緊張素-醛固酮系統(tǒng)　切入點：基因多態(tài)　出處：《北京體育大學(xué)學(xué)報》2017年05期

【摘要】：目的:探討腎素-血管緊張素-醛固酮系統(tǒng)(RAAS)基因多態(tài)與男性原發(fā)性高血壓患者不同強(qiáng)度有氧運(yùn)動降壓效果的關(guān)系,為制定個性化運(yùn)動處方提供依據(jù)。方法:78名男性原發(fā)性高血壓患者利用聚合酶鏈?zhǔn)椒磻?yīng)(PCR)測定血管緊張素轉(zhuǎn)化酶(ACE)基因I/D、血管緊張素II 1型受體(AT1R)基因A/C和醛固酮合酶(CYP11B2)基因T/C多態(tài)。所有受試者分別以60%6)VO2max進(jìn)行1次中等強(qiáng)度有氧運(yùn)動實驗(MAET)、以40%6)VO2max進(jìn)行1次低強(qiáng)度有氧運(yùn)動實驗(LAET)以及1次安靜對照實驗(RCT),時間均為40min。每次實驗前后測定24小時動態(tài)血壓(ABP),包括收縮壓(SBP)和舒張壓(DBP)。結(jié)果:各基因型分布頻率均符合哈-溫遺傳平衡定律(P0.05)。與實驗前比較,MAET、LAET后各基因型組血壓水平均顯著性下降(P0.05),RCT后則無顯著性變化(P0.05);LAET后,ACE-DD基因型組SBP低于ACE-II/ID基因型組(P0.05)。LAET后,≥3個RAAS高危等位基因組SBP和DBP均低于≤2個高危等位基因組(P0.05);MAET和RCT后,2組血壓水平均無顯著性差異(P0.05)。結(jié)論:RAAS基因多態(tài)可影響急性有氧運(yùn)動的降壓效應(yīng)。ACE-DD基因型攜帶者低強(qiáng)度有氧運(yùn)動的降壓效果優(yōu)于ACE-I等位基因(II/ID)者;≥3個RAAS高危等位基因患者低強(qiáng)度有氧運(yùn)動的降壓效果優(yōu)于≤2個等位基因變異者;中等強(qiáng)度運(yùn)動以及安靜對照實驗后,血壓無顯著性改變。
[Abstract]:Objective: to investigate the relationship between renin-angiotensin-aldosterone system (Ras) gene polymorphism and the antihypertensive effect of aerobic exercise with different intensity in male patients with essential hypertension.Methods Polymerase chain reaction (PCR) was used to determine the polymorphism of ACE-I / D, AP-1R and CYP11B2 gene in 78 male patients with essential hypertension.All subjects were given a moderate intensity aerobic exercise test with 60%6)VO2max, a low intensity aerobic exercise test with 40%6)VO2max, and a quiet control test for 40 mins.Before and after each experiment, ambulatory blood pressure (ABP) and diastolic blood pressure (DBP) were measured at 24 hours, including systolic blood pressure (SBP) and diastolic blood pressure (DBP).Results: the distribution frequency of all genotypes was in accordance with the law of ha-temperature genetic balance (P0.05A).There was no significant change in the blood pressure level of each genotype group after RCT compared with that before the experiment. The SBP in the ACE-DD genotype group was lower than that in the ACE-II/ID genotype group (P 0.05).There was no significant difference in blood pressure levels between the two groups after RCT and P0.05 alleles (P 0.05), the genomic SBP and DBP of 鈮，

本文編號：1729877