發(fā)布時間：2018-04-03 19:06

  本文選題：系統(tǒng)性紅斑狼瘡　切入點(diǎn)：EB病毒誘導(dǎo)基因　出處：《山東醫(yī)藥》2017年08期

【摘要】：目的探討EB病毒誘導(dǎo)基因2(EBI2)和膽固醇25α7羥化酶CYP7B1在系統(tǒng)性紅斑狼瘡(SLE)發(fā)生、發(fā)展中的作用。方法選取SLE患者20例(觀察組),體檢健康者20例(對照組),采用ELISA法檢測兩組血清EBI2和膽固醇25α7羥化酶CYP7B1水平。根據(jù)SLE疾病活動指數(shù)(SLEDAI)評分,比較觀察組SLEDAI10分者和≥10分者血清EBI2和膽固醇25α7羥化酶CYP7B1水平。結(jié)果觀察組血清EBI2及膽固醇25α7羥化酶CYP7B1水平分別為(2.82±0.60)×10~(-1)、(158.8±22.62)×10~(-1)ng/m L,均高于對照組的(1.89±0.68)×10~(-1)、(89.92±23.78)×10~(-1)ng/m L(P均0.01)。觀察組SLEDAI≥10分13例,SLEDAI10分7例;SLEDAI≥10分者血清EBI2及膽固醇25α7羥化酶CYP7B1水平分別為(3.26±0.35)×10~(-1)、(183.78±17.41)×10~(-1)ng/m L,均高于SLEDAI10分者的(2.20±0.25)×10~(-1)、(130.57±16.19)×10~(-1)ng/m L(P均0.01)。結(jié)論 SLE患者血清EBI2及膽固醇25α7羥化酶CYP7B1水平均升高,二者可能共同參與了SLE的發(fā)生、發(fā)展。
[Abstract]:Objective to investigate the role of Epstein-Barr virus (EBV) inducible gene 2 (EBI2) and cholesterol 25 偽 7 hydroxylase (CYP7B1) in the pathogenesis and development of systemic lupus erythematosus (SLE).Methods the serum EBI2 and cholesterol 25 偽 7 hydroxylase CYP7B1 levels were measured by ELISA method in 20 patients with SLE (observation group) and 20 healthy persons (control group).According to the SLE disease activity index and SLEDAI score, the levels of serum EBI2 and cholesterol 25 偽 7 hydroxylase CYP7B1 were compared between the patients with SLEDAI10 score and those with 鈮，

本文編號：1706514