發(fā)布時間：2018-03-29 19:21

  本文選題：護場　切入點：箍圍法　出處：《中國實驗方劑學(xué)雜志》2017年16期

【摘要】：目的:觀察護場理論指導(dǎo)下紅腫消酊劑箍圍法對皮膚膿腫大鼠創(chuàng)周組織白細胞介素-10(IL-10),白細胞介素-1β(IL-1β)基因表達水平的影響。方法:32只大鼠分為空白組、模型組、莫匹羅星軟膏組及紅腫消酊劑組。除空白組外,其余3組皮下注射金黃色葡萄球菌1 mL(3×10~9~5×10~9cfu·mL~(-1))建立皮下膿腫模型。模型組生理鹽水換藥,莫匹羅星軟膏組采用莫匹羅星軟膏2 g外涂換藥,紅腫消酊劑組采用紅腫消2 mL換藥,用藥范圍超過腫脹范圍1 cm,換藥1次/d。分別于治療3,7,14,18 d取距離大鼠創(chuàng)面創(chuàng)周1,2,3 cm組織,觀察大鼠創(chuàng)面膿腫局限及愈合時間,并檢測IL-10,IL-1βmRNA轉(zhuǎn)錄水平。結(jié)果:與模型組比較,紅腫消酊劑組能夠縮短膿腫局限時間及創(chuàng)面愈合時間(P0.05,P0.01),紅腫消酊劑組與莫匹羅星軟膏組比較無統(tǒng)計學(xué)差異。紅腫消酊劑組距離創(chuàng)周不同范圍組織中IL-10水平在治療過程中呈上升趨勢,高于莫匹羅星軟膏組及模型組,紅腫消酊劑組治療早期IL-1β水平低于莫匹羅星軟膏組及模型組(P0.05,P0.01)。結(jié)論:紅腫消酊劑箍圍能夠提高IL-10水平,并在膿腫形成早期抑制組織內(nèi)IL-1β表達,從而能夠有效減輕膿腫局部炎癥反應(yīng),促進膿腫局限及創(chuàng)面愈合,為護場形成提供條件。
[Abstract]:Objective: to observe the effect of hoop method of Hongzongxiao tincture on the expression of interleukin-10 (IL-10) and interleukin-1 尾 (IL-1 尾) in peripheral tissue of rats with skin abscess under the guidance of nursing field theory. Methods: thirty two rats were divided into blank group and model group. The model of subcutaneous abscess was established by subcutaneous injection of staphylococcus aureus (1 mL(3 脳 10 ~ (9) C) 5 脳 10~9cfu m L ~ ((1)) in the other three groups, except the blank group, in which normal saline was changed into the model group, and the subcutaneous abscess model was established in the mupiroxin ointment group and Hongzongxiao tincture group. Mupiroxine ointment group was treated with 2 g of mupiroxine ointment, and Hongzongxiao tincture group was treated with 2 mL of Hongzongxiao. The drug range was more than 1 cm. The localization and healing time of wound abscess in rats were observed, and the transcription level of IL-10 and IL-1 尾 mRNA were measured. Results: compared with the model group, Hongzongxiao tincture group can shorten the time of abscess localization and wound healing. There is no significant difference between Hongzongxiao tincture group and mupiroxine ointment group. The level of IL-10 in different tissues of Hongzongxiao tincture group is treated in different range. There is an upward trend in the process, The level of IL-1 尾 in the tincture group of Hongzongxiao was lower than that in the group of mupiroxine ointment and the model group. Conclusion: the hoop circumference of Hongzongxiaoxiao can increase the level of IL-10 and inhibit the expression of IL-1 尾 in tissues at the early stage of abscess formation. It can effectively reduce the local inflammatory reaction of abscess, promote the localization of abscess and wound healing, and provide conditions for the formation of nursing site.
【作者單位】： 天津中醫(yī)藥大學(xué)第二附屬醫(yī)院;天津醫(yī)院;天津中醫(yī)藥大學(xué);
【基金】：國家自然科學(xué)基金項目(81273759)
【分類號】：R285.5

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