本文選題：糖尿病　切入點(diǎn)：視網(wǎng)膜病變　出處：《東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年06期

【摘要】：目的:探討晚期糖基化終產(chǎn)物受體基因(RAGE)-374T/A及-429T/C多態(tài)性與糖尿病視網(wǎng)膜病變神經(jīng)細(xì)胞凋亡的相關(guān)性。方法:選取350例糖尿病患者(150例伴視網(wǎng)膜病變,200例不伴視網(wǎng)膜病變)與150例健康人群作為研究對(duì)象,比較分析各組患者RAGE基因-374T/A及-429T/C多態(tài)性等位基因和基因型頻率的分布情況以及受試者臨床基本特征。結(jié)果:RAGE基因-429T/C多態(tài)性的基因型和等位基因頻率與糖尿病視網(wǎng)膜病變的發(fā)生無顯著相關(guān)性(P0.05);糖尿病伴視網(wǎng)膜病變組RAGE基因-374T/A多態(tài)性的A等位基因頻率高于不伴視網(wǎng)膜病變組(P0.05)。結(jié)論:晚期糖基化終產(chǎn)物受體基因-374T/A多態(tài)性可能通過引起糖尿病患者的神經(jīng)細(xì)胞凋亡進(jìn)而導(dǎo)致視網(wǎng)膜病變發(fā)生。
[Abstract]:Objective: to investigate the relationship between late glycation end product receptor gene RAGE-374T / A and -429T / C polymorphism and neuronal apoptosis in diabetic retinopathy. Methods: 150 patients with diabetic retinopathy and 200 patients without retinopathy were selected. ) and 150 healthy people as subjects, The distribution of alleles and genotype frequencies of RAGE gene -374T / A and -429T / C polymorphism in each group and the basic clinical characteristics of the subjects were compared and analyzed. Results the genotype and allele frequencies of -429T / C polymorphism of the RAGE gene and the diabetic visual network were compared and analyzed. The frequency of A allele of RAGE gene -374T / A polymorphism in diabetic patients with retinopathy was higher than that in patients without retinopathy. Conclusion: the late glycation end product receptor gene -374T / A polymorphism may be higher than that in the patients without retinopathy. Retinopathy occurs by inducing neuronal apoptosis in diabetic patients.
【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院眼科;綿陽市中心醫(yī)院眼科;
【分類號(hào)】：R587.2;R774.1
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本文編號(hào)：1661049