本文選題：法醫(yī)遺傳學(xué)　切入點：短串聯(lián)重復(fù)序列(STR)　出處：《陜西師范大學(xué)學(xué)報(自然科學(xué)版)》2017年05期 　論文類型：期刊論文

【摘要】：對寧夏回族和漢族人群15個STR基因座的遺傳多態(tài)性進行調(diào)查,應(yīng)用Identifiler Plus試劑盒檢測598名寧夏回族、598名寧夏漢族無關(guān)個體15個STR基因座的DNA分型,使用Modified-Powerstates統(tǒng)計軟件計算等位基因分布頻率等法醫(yī)遺傳學(xué)數(shù)據(jù)。實驗發(fā)現(xiàn):寧夏回族和漢族人群的15個STR基因座基因型分布符合Hardy-Weinberg平衡定律(P0.05),寧夏回族群體15個基因座的雜合度(H)在0.659~0.858之間,匹配概率(Pm)在0.037~0.147之間,個體識別概率(DP)在0.798~0.963之間,多態(tài)信息含量(PIC)在0.570~0.850之間,非父排除概率(PE)值在0.368~0.710之間;寧夏漢族群體15個基因座的雜合度(H)在0.587~0.878之間,匹配概率(Pm)在0.035~0.211之間,個體識別概率(DP)在0.789~0.965之間,多態(tài)信息含量(PIC)在0.550~0.850之間,非父排除概率(PE)值在0.342~0.751之間。結(jié)果表明,寧夏回族人群和漢族人群15個STR基因座具有較高的遺傳多態(tài)性分布特征,可為寧夏人口親權(quán)鑒定、個體識別及群體遺傳學(xué)研究提供基礎(chǔ)。
[Abstract]:The genetic polymorphisms of 15 STR loci in Hui and Han populations in Ningxia were investigated. The DNA genotyping of 15 STR loci in 598 unrelated individuals of Ningxia Hui nationality was detected by Identifiler Plus kit. Using Modified-Powerstates statistical software to calculate the frequency of allele distribution and other forensic genetic data. It was found that the genotype distribution of 15 STR loci in Hui and Han populations in Ningxia conforms to the Hardy-Weinberg equilibrium law (P0.05A) and 15 genes in Ningxia Hui population. The heterozygosity of the pedestal is between 0. 659 and 0. 858. The matching probability (Pm) was between 0.037 and 0.147, the individual identification probability was between 0.7980.63, the polymorphic information content was between 0.570 and 0.850, the non-paternal exclusion probability was 0.3680.700.10, and the heterozygosity of 15 loci in Ningxia Han population was between 0.5870.878. The matching probability (Pm) is between 0.035 and 0.211, the individual identification probability is between 0.789 and 0.965, the polymorphic information content is between 0.550 and 0.850, and the non-paternal exclusion probability is between 0.342 and 0.751. The results show that. The 15 STR loci of Hui and Han populations in Ningxia had high genetic polymorphism distribution characteristics, which could provide a basis for paternity identification, individual identification and population genetics research in Ningxia population.
【作者單位】： 陜西師范大學(xué)物理學(xué)與信息技術(shù)學(xué)院;
【基金】：國家自然科學(xué)基金(21402114) 陜西省自然科學(xué)基礎(chǔ)研究計劃(2016JM2010) 中央高�；究蒲袠I(yè)務(wù)費專項資金(GK201603026)
【分類號】：R394

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