本文選題：精神分裂癥　切入點：SLC39A8基因　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討SLC39A8基因的單核苷酸多態(tài)性(single nucleotide polymorphism,SNP)與精神分裂癥的發(fā)病是否相關(guān)。方法:研究對象來自新疆地區(qū)的維吾爾族人群。采用病例-對照研究(case-control study),納入985例維吾爾族精神分裂癥(Schizophrenia,SC)患者及1218例維吾爾族非精神分裂癥對照。測定兩組的SLC39A8基因rs13107325位點的基因型。結(jié)果:SLC39A8基因rs13107325位點多態(tài)性與精神分裂癥的發(fā)病有關(guān)(P_(allele)=0.018,P_(genotype)=0.0004,odds ratio(OR)=1.310,95%CI=1.048-1.650),其中基因型C/T(P=0.735,OR=0.958,95%CI=0.757-1.241)和基因型C/C(P=0.261,OR=0.981,95%CI=0.949-1.014)與精神分裂癥發(fā)病無關(guān);等位基因C(P=0.018,OR=0.760,95%CI=0.604-0.955)與精神分裂癥的發(fā)病成負(fù)關(guān)聯(lián);而基因型T/T(P=0.0004,OR=4.28,95%CI=1.913-9.186)和等位基因T(P=0.018,OR=1.310,95%CI=1.044-1.594)則與精神分裂癥的發(fā)病成正關(guān)聯(lián),為精神分裂癥發(fā)病的危險因素。結(jié)論:在中國新疆維吾爾族人群中,SLC39A8基因rs13107325位點可能增加新疆維吾爾族人群精神分裂癥的易感性。
[Abstract]:Objective: to investigate whether the single nucleotide polymorphism (SNP) of SLC39A8 gene is associated with the onset of schizophrenia. Methods: a case-control study was conducted to study the incidence of schizophrenia in Uygur ethnic groups from Xinjiang. A case-control study was conducted to include 985 cases of Uygur. The genotypes of rs13107325 locus of SLC39A8 gene in two groups were determined. Results the polymorphism of rs13107325 locus of SLC39A8 gene was associated with the onset of schizophrenia. Results the incidence of schizophrenia was related to the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was no correlation between the incidence of schizophrenia and the genotype C / P 0.261 (0.981C 0.981C ~ 0.949-1.014), which were related to the incidence of schizophrenia. The results showed that the incidence of schizophrenia was not related to the type of C / T / T / P 0.735 / 0.735 / 0.75 ~ 1.241) and the genotype of C / P _ (0.261) was 0.981C ~ (0.949 ~ 1.014). There was a negative correlation between the genotype T / T / T 0.0004 and 1.913-9.186) and the OR1.31095CI1.044-1.594) and the genotype T / T ~ (0.0004) was positively associated with the onset of schizophrenia, while the genotype T / T ~ (0.0004) and the allele T / T ~ (0.018) OR1.310 95CII 1.044-1.594) were positively associated with the onset of schizophrenia, while the genotype T / T ~ (0.0004) OR1.913-9.186) was positively associated with the onset of schizophrenia. Conclusion: the rs13107325 locus of SLC39A8 gene in Xinjiang Uygur population may increase the susceptibility to schizophrenia in Xinjiang Uygur population.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.3

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本文編號：1568578