本文選題：摻鍶羥基磷灰石 + 兩步電沉積法��； 參考：《浙江大學》2015年碩士論文

【摘要】：本文采用電化學法首先在不同電解液濃度條件下在鈦金屬基底表面沉積羥基磷灰石(HA)涂層,通過分析沉積電流隨時間變化規(guī)律,使用掃描電子顯微鏡(SEM)觀察涂層微觀形貌,使用X射線衍射法(XRD)分析涂層物相組成,研究了隨著電解液濃度的提高,相應地改變沉積電壓和溫度等實驗參數(shù),制備的涂層的微觀形貌和物相的變化規(guī)律,總結出制備HA涂層的實驗規(guī)律。其次也探討了高低兩種濃度的電解液中制備摻鍶羥基磷灰石(SrHA)涂層的實驗條件,結合第一部分實驗所總結的規(guī)律,發(fā)現(xiàn)通過調控沉積電壓、溫度和時間,在兩種電解液中加入一定比例的含鍶電解質參與反應,均可制備出摻鍶比例接近接近預期的SrHA涂層,也證實了Sr2+和Ca2+參與SrHA結晶形核的行為相似。最后采用兩步電沉積法,將高低兩種濃度的電解液條件下的涂層制備結合,并且在進行第二步沉積的高濃度電解液中加入重要的反應介質檸檬酸三鈉(Na3Cit)。第二步沉積中,在檸檬酸根的吸附作用下晶核在原有的棒狀結構側面聚集組裝,形成荊棘狀結構涂層。體外離子釋放實驗和涂層接觸角測試結果表明,兩步電沉積均摻鍶的荊棘狀結構涂層具有快速的Sr2+釋放速率和最佳的潤濕性。在細胞增殖試驗中,SrHA涂層受各自的Sr2+釋放情況和微觀形貌影響,表現(xiàn)出不同的促進細胞增殖情況,為可控地制備出在物相組成和微觀結構上與人體磷灰石更為接近的生物醫(yī)用材料開辟了新的方向。
[Abstract]:In this paper, the hydroxyapatite (HA) coating was deposited on titanium substrate with different electrolyte concentration by electrochemical method. The microstructure of the coating was observed by scanning electron microscope (SEM) by analyzing the variation of deposition current with time. The phase composition of the coating was analyzed by X-ray diffraction (XRD). With the increase of electrolyte concentration, the microstructure and phase change of the coating were studied by changing the experimental parameters such as deposition voltage and temperature. The experimental rule of HA coating was summarized. Secondly, the experimental conditions of preparing SrHA coating with strontium hydroxyapatite in high or low concentration electrolyte are also discussed. According to the rule summarized in the first part of the experiment, it is found that the deposition voltage, temperature and time can be adjusted by adjusting the deposition voltage, temperature and time. Adding a certain proportion of strontium-containing electrolyte to the two electrolytes to take part in the reaction, the Sr-doped SrHA coatings were prepared, and the behavior of Sr2 and Ca2 participating in the nucleation of SrHA was proved to be similar. Finally, a two-step electrodeposition method was used to prepare the coating under the conditions of high and low concentrations of electrolyte, and an important reaction medium, sodium citrate, was added to the high concentration electrolyte for the second step deposition. In the second step, the crystal nucleus is assembled on the side of the original rod-like structure by the adsorption of citrate to form a thorn-like structure coating. The ion release experiment in vitro and the contact angle test of the coating show that the Sr2 release rate and the wettability of the bramble structure coating with strontium doped in two steps are rapid and the best wettability can be obtained. In the cell proliferation test, the SrHA coating was affected by the release of Sr2 and the microcosmic morphology, and showed different effects on cell proliferation. It opens a new direction for the controllable preparation of biomedical materials which are closer to human apatite in terms of phase composition and microstructure.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：TG174.4

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