本文選題：無機陶瓷材料　切入點：多孔陶瓷　出處：《中國科技論文》2017年10期 　論文類型：期刊論文

【摘要】：針對多孔磷酸鈣生物陶瓷難以平衡力學性能與孔隙率和孔連通性的關(guān)系問題,采用結(jié)合擠出成型法和造孔劑法制備了三維連通孔磷酸鈣生物陶瓷。使用X射線衍射儀和掃描電鏡對多孔磷酸鈣生物陶瓷的物相和形貌進行了表征,測試了材料的抗壓強度和孔隙率,評價了細胞學性能。測試結(jié)果表明:所制備的多孔磷酸鈣生物陶瓷的物相為純相的β相磷酸三鈣;擠出形成的直通宏孔規(guī)則排列,孔徑約為400μm;在三維連通孔磷酸鈣生物陶瓷的直通宏孔孔壁上隨機分布著橫向連通孔,這些橫向連通孔將相鄰的直通宏孔貫通起來,形成三維連通的孔結(jié)構(gòu);單純直通孔和三維連通孔磷酸鈣生物陶瓷的孔隙率分別為60%和70%,抗壓強度(平行于直通宏孔方向)分別為20和5MPa。細胞學實驗表明,所制備的多孔磷酸鈣生物陶瓷具有良好的細胞黏附能力,三維連通孔磷酸鈣生物陶瓷比單純直通孔磷酸鈣生物陶瓷具有更強的細胞增殖能力,但成骨分化能力低于單純直通孔磷酸鈣生物陶瓷。因此,結(jié)合擠出成型法和造孔劑法是1種制備具有三維連通、高抗壓強度多孔磷酸鈣生物陶瓷的有效方法。
[Abstract]:In view of the relationship between the imbalanced mechanical properties of porous calcium phosphate bioceramics and porosity and pore connectivity, Three-dimensional porous calcium phosphate bioceramics were prepared by combining extrusion molding method and pore making agent method. The phase and morphology of porous calcium phosphate bioceramics were characterized by X-ray diffraction and scanning electron microscopy. The compressive strength and porosity of the materials were tested, and the cytological properties were evaluated. The results showed that the phase of the porous calcium phosphate bioceramics was pure phase 尾 -tricalcium phosphate, and the straight through macropores were arranged regularly. The pore size is about 400 渭 m, and the transverse connected pores are randomly distributed on the wall of the straight through macro holes of the three-dimensional connected porous calcium phosphate bioceramics, which make the adjacent straight through macro holes through and form a three-dimensional connected pore structure. The porosity of pure through pore and three dimensional connected pore calcium phosphate bioceramics were 60% and 70, respectively, and the compressive strength (parallel to the direction of straight through macro pore) were 20 and 5 MPa, respectively. The porous calcium phosphate bioceramics have good cell adhesion, and the three-dimensional porous calcium phosphate bioceramics have stronger cell proliferation ability than the straight through porous calcium phosphate bioceramics. However, the osteogenic differentiation ability is lower than that of pure through pore calcium phosphate bioceramics. Therefore, the combination of extrusion molding method and pore making agent method is an effective method for the preparation of porous calcium phosphate bioceramics with three-dimensional connectivity and high compressive strength.
【作者單位】： 華南理工大學材料科學與工程學院;生物醫(yī)學材料與工程教育部重點實驗室;廣東工業(yè)大學機電工程學院;國家人體組織功能重建工程技術(shù)研究中心;
【基金】：高等學校博士學科點專項科研基金資助項目(20130172110006) 廣州市珠江科技新星項目(201710010149)
【分類號】：TQ174.6

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