本文關(guān)鍵詞： 電感耦合等離子體發(fā)射光譜(ICP-AES)法 玻璃類藥包材 包裝材料 金屬元素浸出量 多元素同時(shí)測(cè)定　出處：《藥物分析雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的:建立同時(shí)測(cè)定玻璃類藥包材中鋁(Al)、鋇(Ba)、鎘(Cd)、鉻(Cr)、銅(Cu)、鐵(Fe)、錳(Mn)、鉛(Pb)、銻(Sb)、鋅(Zn)、鈰(Ce)共11種元素的浸出量的分析方法,測(cè)定樣品,為提高現(xiàn)有標(biāo)準(zhǔn)提供支持和參考。方法:4%醋酸溶液對(duì)玻璃藥包材進(jìn)行浸提,采用電感耦合等離子體發(fā)射光譜(ICP-AES)法測(cè)定浸提液中11種元素的濃度,高頻功率為1.2 k W,等離子體氣體流速為10 L·min~(-1),分析譜線分別為:394.403(Al)、233.527(Ba)、214.438(Cd)、267.716(Cr)、324.754(Cu)、259.94(Fe)、257.61(Mn)、220.353(Pb)、217.581(Sb)、202.548(Zn)、418.66(Ce)。結(jié)果:該方法同時(shí)測(cè)定Al、Ba、Cd、Cr、Cu、Fe、Mn、Pb、Sb、Zn、Ce,各元素在一定的濃度范圍內(nèi)呈良好的線性關(guān)系,線性相關(guān)系數(shù)為0.999 1~1.000;加樣回收率為85.8%~106.0%;精密度試驗(yàn)的RSD為0.4%~1.8%;重復(fù)性試驗(yàn)的RSD為0.6%~4.8%;檢出限為0.52~75.17 ng·mL~(-1)。測(cè)定樣品16批,結(jié)果測(cè)得Al浸出量最高為376.5 ng·mL~(-1),Ba浸出量最高為212 ng·mL~(-1),其他元素浸出量均較低,大多為未檢出。結(jié)論:該方法可用于同時(shí)測(cè)定玻璃類藥包材中多種元素的浸出量。結(jié)果顯示Al浸出量較高,澄清劑氧化鈰應(yīng)用廣泛,建議相關(guān)標(biāo)準(zhǔn)中增加Al、Ce浸出量的測(cè)定方法。
[Abstract]:Objective: to establish a method for the simultaneous determination of the leaching amount of 11 elements in glass inclusions, such as Al _ 2O _ 3, Ba ~ (3 +), CD ~ (2 +), CD ~ (2 +), Cr ~ (3 +), Cu ~ (2 +), Fe ~ (2 +), Fe ~ (2 +), mn ~ (2 +) Mn-MnN, Pb ~ (2 +), Pb ~ (2 +), SB ~ (2 +), Zn ~ (2 +), Zn ~ (2 +), ce ~ (2 +). In order to improve the existing standards, the concentration of 11 elements in the solution was determined by ICP-AESS-ICP-AES. The high frequency power is 1.2 kW, the flow rate of plasma gas is 10 L 路min ~ (-1). The analytical lines are: 394.403Alnum 233.527, respectively. The analytical lines are: 1: 214.438 ~ (3) ~ (2) ~ (2) (43.438) ~ (2) ~ (2) ~ (24. 754) C ~ (2 +) ~ (324.754) C ~ (2 +) ~ (259.94) Fe257.61m ~ (217.558) ~ (th) ~ (217.558) ~ (th) ~ (?) ~ (418.66) Ce.Results: this method can be used for the simultaneous determination of Alba BaCdCrCU Cu (FeMnCrn) PbPbn (Febn) in a certain range of concentrations. There is a good linear relationship between the elements in a certain concentration range, and the results show that there is a good linear relationship between the two elements in a certain concentration range. The linear correlation coefficient was 0.999 1 ~ 1.000; the recovery rate was 85.80.The RSD of the precision test was 0.4 and 1.8; the RSD of the reproducibility test was 0.6and 4.8. the detection limit was 0.52 ~ 75.17 ng 路mL ~ (-1). Sixteen batches of samples were determined. The results showed that the highest leaching amount of Al was 376.5 ng 路mL ~ (-1) ~ (-1) Ba, the highest was 212 ng 路mL ~ (-1) 路L ~ (-1) of Al, and the leaching amount of other elements was lower than that of other elements. Conclusion: this method can be used to simultaneously determine the leaching amount of many elements in glass materials. The results show that Al leaching amount is high and cerium oxide is widely used.
【作者單位】： 湖南省醫(yī)療器械檢驗(yàn)檢測(cè)所;中國(guó)食品藥品檢定研究院包裝材料與藥用輔料檢定所;
【分類號(hào)】：TQ171.74;O657.31
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本文編號(hào)：1496123