小兒七星茶口服液指紋圖譜研究
發(fā)布時(shí)間：2019-05-17 22:56
【摘要】：目的建立小兒七星茶口服液HPLC指紋圖譜,表征小兒七星茶口服液的化學(xué)成分信息。方法采用HPLC法建立指紋圖譜并用液質(zhì)聯(lián)用儀鑒定指紋圖譜主要色譜峰。采用Ultimate AQ-C18色譜柱(150 mm×4.6 mm,5μm);以乙腈-0.1%冰醋酸溶液為流動(dòng)相進(jìn)行梯度洗脫;檢測(cè)波長(zhǎng)為300 nm;柱溫為30℃;體積流量為1.0 m L/min。結(jié)果建立了小兒七星茶口服液HPLC指紋圖譜,確認(rèn)并鑒別出共有特征峰12個(gè),21批樣品的相似度達(dá)0.89以上;方法學(xué)考察的精密度、重復(fù)性相似度均達(dá)1.0,36 h內(nèi)樣品穩(wěn)定性相似度達(dá)0.98。結(jié)論所建立的方法穩(wěn)定、可靠、重復(fù)性好,可用于小兒七星茶口服液質(zhì)量控制。
[Abstract]:Objective to establish HPLC fingerprint of Xiaoer Qixing tea oral liquid and characterize the chemical composition information of Xiaoer Qixing tea oral liquid. Methods the fingerprint was established by HPLC and the main chromatographic peaks were identified by liquid mass spectrometry. A Ultimate AQ-C18 column (150 mm 脳 4.6 mm, 5 渭 m) was used, the mobile phase was acetonitrile-0.1% acetic acid solution for gradient elution, the detection wavelength was 300 nm; column temperature was 30 鈩，
本文編號(hào)：2479470
[Abstract]:Objective to establish HPLC fingerprint of Xiaoer Qixing tea oral liquid and characterize the chemical composition information of Xiaoer Qixing tea oral liquid. Methods the fingerprint was established by HPLC and the main chromatographic peaks were identified by liquid mass spectrometry. A Ultimate AQ-C18 column (150 mm 脳 4.6 mm, 5 渭 m) was used, the mobile phase was acetonitrile-0.1% acetic acid solution for gradient elution, the detection wavelength was 300 nm; column temperature was 30 鈩，
本文編號(hào)：2479470
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