【摘要】：設(shè)計(jì)以簡單易得合成子β-烯胺酮1為原料,以氰基乙酸2為�；噭�,得到烯胺酮的α-C區(qū)域選擇性氰基乙酰化產(chǎn)物3.進(jìn)而從化合物3出發(fā),以乙腈為溶劑,哌啶為催化劑,在40℃下,通過分子內(nèi)環(huán)合反應(yīng),簡潔、高效合成了一類結(jié)構(gòu)新穎的喹啉酮類雜環(huán)化合物4a~4t,產(chǎn)率82~95%.該方法具有操作簡便、原子經(jīng)濟(jì)、原料易得、后處理簡單等優(yōu)點(diǎn).
[Abstract]:The 偽 -C region-selective cyanoacetylation product 3of enamine ketone was prepared by using simple and easy synthesis of 尾 -enamine ketone 1 as raw material and cyanoacetic acid 2 as acylation reagent. From compound 3, using acetonitrile as solvent and piperidine as catalyst, a class of novel quinolinone heterocyclic compounds 4a1 4t was synthesized by intramolecular cyclization at 40 鈩，

本文編號：2406589