【摘要】：溶液制備是化學(xué)分析、醫(yī)藥衛(wèi)生等實(shí)驗(yàn)室最基本的工作內(nèi)容之一。雖然分析化學(xué)、生物分析等學(xué)科正在快速發(fā)展,但高精度的自動(dòng)化溶液制備系統(tǒng)仍然發(fā)展緩慢,在精度要求較高的樣品處理上大多還使用人工處理的方式。人工配液具有耗時(shí)長、操作繁瑣、精度低等問題,因此,開發(fā)精度高且操作簡(jiǎn)便的自動(dòng)化溶液制備系統(tǒng)取代人工配液必將成為一種趨勢(shì)。本文在分析國內(nèi)外溶液制備系統(tǒng)發(fā)展現(xiàn)狀的基礎(chǔ)上,設(shè)計(jì)了一種具有通用性的高精度自動(dòng)化溶液制備系統(tǒng),該系統(tǒng)具有精確配制、比例稀釋、等量分配和可二次開發(fā)等功能,并且能根據(jù)需要將同一過程全自動(dòng)地重復(fù)執(zhí)行。溶液制備系統(tǒng)采用智能化設(shè)計(jì),具有操作簡(jiǎn)單、配液方便、配液精度高等優(yōu)點(diǎn)。系統(tǒng)由上位機(jī)模塊、下位機(jī)通信模塊、下位機(jī)主控模塊、管道切換模塊、管道切換模塊驅(qū)動(dòng)電路、自動(dòng)進(jìn)樣器模塊、自動(dòng)進(jìn)樣器模塊驅(qū)動(dòng)電路7個(gè)部分組成。其中,下位機(jī)主控模塊、管道切換模塊、管道切換模塊驅(qū)動(dòng)電路、自動(dòng)進(jìn)樣器模塊和自動(dòng)進(jìn)樣器模塊驅(qū)動(dòng)電路構(gòu)成下位機(jī)執(zhí)行系統(tǒng),便于用戶二次開發(fā)使用。下位機(jī)主控模塊以STM32F103作為核心芯片,進(jìn)行自動(dòng)進(jìn)樣、管道切換的控制。下位機(jī)通信模塊使用CC2540和STM32F103組合的控制板,實(shí)現(xiàn)無線接收手機(jī)指令并發(fā)送控制指令的功能。上位機(jī)模塊采用Android手機(jī),完成功能參數(shù)的設(shè)定與動(dòng)作過程的顯示。本文完成的主要工作包括以下幾個(gè)方面:(1)查閱相關(guān)文獻(xiàn),分析當(dāng)前溶液制備系統(tǒng)的原理與組成。以稀釋過程為研究對(duì)象制定設(shè)計(jì)方案,選擇了合適的柱塞泵、管道和切換閥。(2)針對(duì)精確配制、比例稀釋、等量分配和二次開發(fā)功能,設(shè)計(jì)溶液制備系統(tǒng)硬件電路與軟件程序,實(shí)現(xiàn)自動(dòng)化高精度配液。(3)對(duì)溶液制備系統(tǒng)進(jìn)行實(shí)驗(yàn)測(cè)試。通過比例稀釋實(shí)驗(yàn)測(cè)試系統(tǒng)的取樣精度、準(zhǔn)確度與取樣速度。通過等量分配實(shí)驗(yàn)測(cè)試系統(tǒng)穩(wěn)定性。將實(shí)驗(yàn)結(jié)果分別進(jìn)行原子吸收與質(zhì)譜分析,分析結(jié)果表明,系統(tǒng)可以完全滿足常規(guī)溶液配制的標(biāo)準(zhǔn)要求,不但取樣準(zhǔn)確、重復(fù)性好,而且也可以大量節(jié)省實(shí)驗(yàn)室人員的工作時(shí)間以及化學(xué)試劑的用量。
[Abstract]:Solution preparation is one of the most basic contents of chemical analysis, medicine and health laboratory. Although analytical chemistry, biological analysis and other disciplines are developing rapidly, high-precision automated solution preparation systems are still slow to develop, and manual processing is mostly used in sample processing with high precision. It is a trend to develop an automatic solution preparation system with high precision and simple operation to replace the artificial liquid dispensing system because of its long time consuming, complicated operation and low precision. Based on the analysis of the present situation of solution preparation system at home and abroad, a universal and high precision automatic solution preparation system is designed. The system has the functions of accurate preparation, proportional dilution, equal distribution and redevelopment. And can carry out the same process automatically and repeatedly according to the need. The solution preparation system is designed intelligently, which has the advantages of simple operation, convenient distribution and high precision. The system consists of upper computer module, lower computer communication module, master control module of lower computer, driving circuit of pipeline switching module and driving circuit of automatic sampler module. Among them, the main control module of the lower computer, the driving circuit of the pipeline switching module, the driving circuit of the automatic sampler module and the automatic sampler module constitute the execution system of the lower computer, which is convenient for the user to develop and use again. The main control module of the lower computer takes STM32F103 as the core chip to control automatic injection and pipeline switching. The communication module of the lower computer uses the control board combined with CC2540 and STM32F103 to realize the function of receiving and sending the command of the mobile phone wirelessly. The upper computer module uses Android mobile phone to complete the setting of function parameters and the display of action process. The main work of this paper includes the following aspects: (1) the principle and composition of the current solution preparation system are analyzed by consulting the relevant literature. Taking the dilution process as the object of study, the design scheme was formulated, and suitable piston pumps, pipes and switching valves were selected. (2) aiming at accurate preparation, proportional dilution, equal distribution and secondary development function, The hardware circuit and software program of the solution preparation system are designed to realize the automatic and high precision solution distribution. (3) the solution preparation system is tested experimentally. The sampling precision, accuracy and sampling speed of the system are measured by proportional dilution experiment. The stability of the system is tested by the equal distribution experiment. The experimental results were analyzed by atomic absorption spectrometry and mass spectrometry respectively. The results show that the system can completely meet the standard requirements of conventional solution preparation, and not only the sampling is accurate, but also the repeatability is good. And can also save a lot of laboratory staff working time and the amount of chemical reagents.
【學(xué)位授予單位】：東北師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O645

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