【摘要】：采用電化學(xué)聚合法制備了聚鉻黑T膜修飾電極,應(yīng)用掃描電鏡、交流阻抗法和循環(huán)伏安法對(duì)修飾電極進(jìn)行表征,以循環(huán)伏安法研究硫酸特布他林在修飾電極上的電化學(xué)行為,并以差示脈沖伏安法對(duì)其含量進(jìn)行測(cè)定.該方法對(duì)硫酸特布他林有明顯的電催化作用,在pH 7.0磷酸鹽緩沖液中,氧化峰電流與硫酸特布他林濃度在1.2×10~(-7)~2.0×10~(-6) mol·L~(-1)范圍內(nèi)呈良好的線性關(guān)系,檢測(cè)限為1.5×10~(-8)mol·L~(-1),回收率在97.9%~104.6%之間,RSD在2.8%(C=8×10~(-7)mol·L~(-1),n=11).該方法簡(jiǎn)便靈敏,結(jié)果準(zhǔn)確可靠,方法重復(fù)性好,可用于硫酸特布他林及其片劑的質(zhì)量控制.
[Abstract]:The modified electrode was prepared by electrochemical polymerization. The modified electrode was characterized by SEM, AC impedance and cyclic voltammetry. The electrochemical behavior of terbutaline sulfate on modified electrode was studied by cyclic voltammetry. The content was determined by differential pulse voltammetry. The method has obvious electrocatalytic effect on terbutaline sulfate in pH 7.0 phosphate buffer. There was a good linear relationship between the oxidation peak current and the concentration of terbutaline sulfate in the range of 1.2 脳 10 ~ (-7) ~ 2.0 脳 10 ~ (-6) mol L ~ (-1). The detection limit was 1.5 脳 10 ~ (-8) mol L ~ (-1). The recovery was between 97.9% and 104.6%, and the RSD was 2.8% (CX 8 脳 10 ~ (-7) mol L ~ (-1), n ~ (11). The method is simple, sensitive, accurate and reliable. It can be used for the quality control of terbutaline sulfate and its tablets.
【作者單位】： 福建醫(yī)科大學(xué)藥學(xué)院藥物分析系;福建省高等學(xué)校納米醫(yī)藥技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家863計(jì)劃項(xiàng)目(No.2012AA022604) 國(guó)家自然科學(xué)基金(No.81171668,No.21405015) 福建省教育廳科技A類項(xiàng)目(No.JA13147) 大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(No.201410392034,No.201510392099)資助
【分類號(hào)】：TQ460.72;O657.1

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