【摘要】：透明質酸是由葡萄糖醛酸和N-乙酰葡萄糖胺組成的雙糖單位聚合而成的直鏈酸性粘多糖,在醫(yī)藥、化妝品、食品等領域擁有龐大的市場。傳統(tǒng)研究通過優(yōu)化發(fā)酵參數改善透明質酸的生產雖然取得了顯著成效,但也趨于上限,加之天然生產菌株固有的發(fā)酵培養(yǎng)基成本高、具有一定致病性等等的劣勢也日益顯著。隨著分子生物學技術的迅速發(fā)展以及對透明質酸合成相關基因研究的不斷深入,研究重點逐漸轉向利用基因工程技術構建高產、安全、具有特定分子量的透明質酸工程菌株。以下就有關透明質酸生產菌株基因工程改造的策略及研究進展進行概述和展望。
[Abstract]:Hyaluronic acid is a straight chain acid mucopolysaccharide which is composed of glucuronic acid and N-acetylglucosamine. It has a large market in medicine, cosmetics, food and other fields. Although the traditional research through optimizing fermentation parameters to improve the production of hyaluronic acid has achieved remarkable results, but also tends to the upper limit, coupled with the natural production strains inherent in the high cost of fermentation medium, with a certain pathogenicity and other disadvantages are increasingly significant. With the rapid development of molecular biology technology and the research of hyaluronic acid biosynthesis related genes, the focus of the research has gradually turned to the use of genetic engineering technology to construct high-yield, safe, with a specific molecular weight of hyaluronic acid engineering strains. The following is a review of the strategies and advances in genetic engineering of hyaluronic acid producing strains.
【作者單位】： 南京理工大學;
【基金】：國家“863”計劃資助項目(2014AA022107)
【分類號】：O636.1

【相似文獻】

相關碩士學位論文 前1條

1 畢傳林;N-乙酰葡萄糖胺轉移酶（OGT）的活性位點研究[D];中國海洋大學;2014年

，

本文編號：2288969