【摘要】：隨著微流體系統(tǒng),尤其是生物芯片及芯片實(shí)驗(yàn)室技術(shù)的發(fā)展,微流動(dòng)測(cè)量技術(shù)越來(lái)越引起人們的注意。與宏觀流動(dòng)相比,微流體系統(tǒng)中的微流動(dòng)更為復(fù)雜和多樣,因此宏觀流動(dòng)測(cè)量技術(shù)移植的方法不可行,急需根據(jù)微流動(dòng)的特點(diǎn)研發(fā)全新的測(cè)量技術(shù)。本文針對(duì)液晶引流微驅(qū)動(dòng)方式的特點(diǎn),研究溫度變化引起的液晶微流動(dòng)測(cè)量技術(shù)。研究成果可以豐富微流體驅(qū)動(dòng)領(lǐng)域研究方法,為液晶引流驅(qū)動(dòng)的應(yīng)用奠定堅(jiān)實(shí)的基礎(chǔ)。本論文所研究的主要內(nèi)容如下:(1)測(cè)量系統(tǒng)關(guān)鍵儀器設(shè)計(jì)制作部分:溫度變化是引起液晶微流動(dòng)的關(guān)鍵因素,因此,測(cè)量系統(tǒng)必須首先能夠?qū)崿F(xiàn)對(duì)溫度的精確控制。本研究運(yùn)用半導(dǎo)體實(shí)現(xiàn)加熱或者制冷的功能,3D打印技術(shù)進(jìn)行加工制造,單片機(jī)及溫度傳感器作為控制系統(tǒng)設(shè)計(jì)制作了一種低電壓經(jīng)濟(jì)型的顯微鏡電冷熱臺(tái)。可實(shí)現(xiàn)功能為:(1)可精確控制樣品的升/降/恒溫過(guò)程;(2)可同時(shí)施加電場(chǎng)。與國(guó)外同類(lèi)型的產(chǎn)品相比價(jià)格低,適于一般實(shí)驗(yàn)室使用;(2)測(cè)量系統(tǒng)硬件搭建及測(cè)量實(shí)驗(yàn)部分:所搭建的測(cè)量系統(tǒng)硬件包括微流動(dòng)流場(chǎng)激發(fā)、微流動(dòng)觀察及數(shù)據(jù)記錄三大部分,并用該系統(tǒng)進(jìn)行了溫度變化引起的液晶微流動(dòng)測(cè)量實(shí)驗(yàn)。實(shí)驗(yàn)過(guò)程分為兩個(gè)階段:(1)運(yùn)用自制電冷熱臺(tái)精確控制溫度的變化,實(shí)現(xiàn)形成大面積穩(wěn)定液晶缺陷的初步目標(biāo)。(2)通過(guò)溫度的變化,測(cè)量液晶缺陷相互作用時(shí)發(fā)生的液晶微流動(dòng),獲得了大量實(shí)驗(yàn)數(shù)據(jù);(3)測(cè)量實(shí)驗(yàn)結(jié)果圖像處理部分:這部分屬于測(cè)量系統(tǒng)的軟件部分,通過(guò)對(duì)測(cè)量實(shí)驗(yàn)所得的視頻數(shù)據(jù)進(jìn)行圖像處理,以獲得液晶微流動(dòng)速度等數(shù)據(jù)。處理流程為通過(guò)MATLAB編程實(shí)現(xiàn)對(duì)測(cè)量實(shí)驗(yàn)視頻中特定幀圖像灰度數(shù)據(jù)的提取,由灰度數(shù)據(jù)計(jì)算液晶分子的傾斜角,再將得到的傾斜角帶入流動(dòng)方程組中求取微流動(dòng)的速度等信息;(4)測(cè)量結(jié)果理論驗(yàn)證部分:用分子動(dòng)力學(xué)計(jì)算的方法,對(duì)液晶缺陷形成及消失的溫度進(jìn)行了驗(yàn)證計(jì)算。通過(guò)Material Studio模擬軟件計(jì)算平均液晶分子指向矢在不同溫度下的扭轉(zhuǎn)位移程度,由液晶分子平均相似度表示,進(jìn)而驗(yàn)證液晶缺陷形成的溫度范圍;(5)液晶微流動(dòng)控制實(shí)驗(yàn)部分:在成功測(cè)量了液晶微流動(dòng)的基礎(chǔ)上,運(yùn)用所搭建的系統(tǒng)進(jìn)行了微流動(dòng)控制的拓展研究,利用激光雕刻機(jī)對(duì)液晶盒進(jìn)行特殊處理,雕刻不同的圖案,目的是定位形成不同強(qiáng)度的液晶缺陷,進(jìn)而精確地控制液晶微流動(dòng)的形成位置與過(guò)程。
[Abstract]:With the development of microfluidic system, especially biochip and microchip laboratory technology, microflow measurement technology has attracted more and more attention. Compared with macroscopic flow, microflow in micro-fluid system is more complex and diverse. Therefore, it is not feasible to transplant macro-flow measurement technology, so it is urgent to develop a new measurement technology according to the characteristics of micro-flow. In this paper, the liquid crystal microflow measurement technology caused by temperature change is studied according to the characteristics of liquid crystal drainage microdrive. The research results can enrich the research methods in the field of microfluid drive and lay a solid foundation for the application of liquid crystal drainage drive. The main contents of this thesis are as follows: (1) the design and fabrication of the key instruments of the measurement system: the temperature change is the key factor that causes the liquid crystal microflow. Therefore, the measurement system must be able to realize the accurate control of the temperature first. In this study, a kind of low voltage and economical microscope electric cooling and heating platform is designed and manufactured by using semiconductor function of heating or cooling and 3D printing technology. The single chip microcomputer and temperature sensor are used as control systems. The functions are as follows: (1) accurate control of the rise / drop / constant temperature process of the sample; (2) simultaneous application of electric field. Compared with the foreign products of the same type, it is suitable for general laboratory use. (2) the hardware of the measurement system consists of three parts: the micro-flow field excitation, the micro-flow observation and the data recording, the hardware of the measurement system is composed of three parts: the excitation of micro-flow field, the observation of micro-flow and the recording of data. The liquid crystal microflow measurement experiment caused by temperature change has been carried out with the system. The experimental process is divided into two stages: (1) the temperature change is controlled precisely by the electric cooling and heating platform, and the initial goal of forming a large area stable liquid crystal defect is realized. (2) the liquid crystal microflow occurs when the liquid crystal defect interacts with the liquid crystal defect is measured through the change of the temperature. A large number of experimental data are obtained. (3) the image processing part of the measurement results: this part belongs to the software part of the measurement system. Through the image processing of the video data obtained from the measurement experiment, the liquid crystal microflow velocity and other data can be obtained. The processing flow is that the grayscale data of a specific frame image can be extracted by MATLAB programming, and the tilt angle of liquid crystal molecules can be calculated from the gray data. Then the tilt angle is brought into the flow equations to obtain the velocity of the micro-flow. (4) the theoretical verification of the measurement results: the temperature of liquid crystal defect formation and disappearance is verified and calculated by the method of molecular dynamics calculation. The degree of torsional displacement of the average liquid crystal molecular pointing vector at different temperatures is calculated by Material Studio simulation software, and the average similarity of liquid crystal molecule is used to express the degree of torsional displacement. Then verify the temperature range of liquid crystal defect formation. (5) liquid crystal microflow control experiment part: on the basis of the successful measurement of liquid crystal microflow, the expanded research of microflow control is carried out by using the built system. The laser engraving machine is used to deal with the liquid crystal cell and carve different patterns in order to locate the liquid crystal defect with different intensity and control the position and process of the liquid crystal microflow accurately.
【學(xué)位授予單位】：河南工業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：O753.2

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本文編號(hào)：2198846