【摘要】：以動(dòng)力學(xué)拆發(fā)的方式得到手性己內(nèi)脂的方法多以脂肪酶為催化劑,而酶催化具有單一的底物范圍且價(jià)格較為昂貴的缺點(diǎn),所以發(fā)展其他催化方式仍舊需要探究。報(bào)道了首例以手性磷酸作為催化劑,甲苯為溶劑,芐醇為親核試劑在0℃下對(duì)6-取代七元環(huán)內(nèi)酯進(jìn)行動(dòng)力學(xué)拆分,能夠以中等的對(duì)映選擇性得到手性己內(nèi)酯,并且具有較廣泛的底物范圍。該方法具有反應(yīng)條件簡(jiǎn)單溫和的優(yōu)點(diǎn),彌補(bǔ)了酶催化底物范圍窄且催化劑昂貴的缺點(diǎn)。
[Abstract]:Lipase is used as catalyst to obtain chiral hexanolipid by kinetic disassembly, and enzyme catalysis has the disadvantages of single substrate range and expensive, so it is still necessary to explore other catalytic methods. The first case of chiral phosphoric acid as catalyst, toluene as solvent, benzyl alcohol as nucleophile reagent for kinetic resolution of 6-substituted heptylcyclolactone at 0 鈩，

本文編號(hào)：2136315