本文選題：乙基化殼聚糖膜 + 丁基化殼聚糖膜��； 參考：《青島科技大學(xué)》2017年碩士論文

【摘要】：烷基化殼聚糖膜是一種重要的高分子膜,具有抑菌性、可降解性、生物相容性等優(yōu)良性能,在醫(yī)藥領(lǐng)域得到廣泛應(yīng)用。因此對(duì)烷基化殼聚糖膜的制備研究得到了廣大學(xué)者的關(guān)注。本文利用殼聚糖(Mr:117×105,D.D.:95.2%)微波堿化的方法制備乙基化殼聚糖,改變反應(yīng)時(shí)間得到不同取代度的乙基化殼聚糖原料,并在常規(guī)醋酸(HAc)體系下制備成膜,考察膜的力學(xué)性能,找出高取代度、高性能的乙基化殼聚糖原料。實(shí)驗(yàn)得出反應(yīng)時(shí)間為4 h時(shí),乙基化殼聚糖的取代度最大為23.5%,膜的斷裂強(qiáng)度最強(qiáng)為220.5 MPa。在常規(guī)醋酸(HAc)體系和1-羧甲基-3-甲基咪唑氯鹽([Acmim]Cl)與甘氨酸鹽酸鹽([Gly]Cl)的按質(zhì)量比混合的二元離子液體體系下將乙基化殼聚糖原料制備成膜,優(yōu)化膜的制備工藝。實(shí)驗(yàn)得出,HAc體系乙基化殼聚糖膜的斷裂強(qiáng)度為266.1 MPa,斷裂伸長(zhǎng)率為17.0%,初始模量為2.3 GPa。二元離子液體體系乙基化殼聚糖膜的斷裂強(qiáng)度為168.6MPa,斷裂伸長(zhǎng)率為11.4%,初始模量為3.6 GPa。結(jié)果表明,HAc體系膜斷裂強(qiáng)度優(yōu)于離子液體體系膜,離子液體體系膜與HAc體系膜相比較表面較光滑,接觸角小,溶脹度較小,透氣性差。對(duì)制備的這兩種膜進(jìn)行血液相容性評(píng)價(jià)得出兩種膜均具有良好的血液相容性。改變反應(yīng)時(shí)間制備不同取代度的丁基化殼聚糖,實(shí)驗(yàn)得出反應(yīng)時(shí)間為4 h時(shí),取代度最大為27.4%,丁基化殼聚糖膜的斷裂強(qiáng)度最強(qiáng)為227.5 MPa。并在HAc體系和[Acmim]Cl與[Gly]Cl按質(zhì)量比混合的二元離子液體體系下制備丁基化殼聚糖膜,優(yōu)化膜的制備工藝。實(shí)驗(yàn)得出,HAc體系丁基化殼聚糖膜的斷裂強(qiáng)度為291.2 MPa,斷裂伸長(zhǎng)率為12.5%,初始模量為1.9 GPa。離子液體體系膜的斷裂強(qiáng)度為191.5 MPa,斷裂伸長(zhǎng)率為12.7%,初始模量為3.4 GPa。結(jié)果表明,HAc體系膜斷裂強(qiáng)度優(yōu)于離子液體體系膜,離子液體體系膜與HAc體系膜相比較表面較粗糙,接觸角小,溶脹度較小,透氣性差。對(duì)制備的這兩種膜進(jìn)行生物相容性評(píng)價(jià)得出兩種膜均具有良好的生物相容性。改變反應(yīng)時(shí)間制備不同取代度的辛基化殼聚糖,得出反應(yīng)時(shí)間為5 h時(shí),取代度最大為23.9%,辛基化殼聚糖膜的斷裂強(qiáng)度最強(qiáng)為231.6 MPa。并在HAc體系和[Acmim]Cl與[Gly]Cl的按質(zhì)量比混合的二元離子液體體系下制備辛基化殼聚糖膜,優(yōu)化膜的制備工藝。實(shí)驗(yàn)得出,HAc體系辛基化殼聚糖膜的斷裂強(qiáng)度為232.0 MPa,斷裂伸長(zhǎng)率為15.8%,初始模量為2.0 GPa。二元離子液體體系辛基化殼聚糖膜的斷裂強(qiáng)度為228.2 MPa,斷裂伸長(zhǎng)率為8.2%,初始模量為3.6 GPa。結(jié)果表明,HAc體系膜斷裂強(qiáng)度優(yōu)于離子液體體系膜,離子液體體系膜與HAc體系膜相比較表面較粗糙,接觸角小,溶脹度較小,透氣性差,對(duì)制備的這兩種膜進(jìn)行血液相容性評(píng)價(jià)得出兩種膜均具有良好的血液相容性。同時(shí)得出,HAc體系膜中丁基化殼聚糖膜的力學(xué)性能最強(qiáng),離子液體體系膜中辛基化殼聚糖膜的力學(xué)性能最強(qiáng)�？傮w來(lái)看HAc體系膜溶脹度、透氣性均高于離子液體膜,作為醫(yī)用材料更容易降解吸收。
[Abstract]:Alkylated chitosan membrane is an important polymer membrane, which has excellent properties such as bacteriostasis, biodegradability and biocompatibility. It has been widely used in the field of medicine. Therefore, the research on the preparation of alkylated chitosan membranes has been paid attention to by many scholars. In this paper, chitosan (Mr:117 * 105, D.D.: 95.2%) is used to prepare B by microwave alkalinity method. The ethyl chitosan material with different degrees of substitution was obtained by changing the reaction time, and the film was prepared under the conventional acetic acid (HAc) system. The mechanical properties of the membrane were investigated and the high substitution degree and high performance ethyl chitosan material was found. The maximum substitution degree of the ethyl chitosan was 23.5% when the reaction time was 4, and the film was broken. The strongest cracking strength is 220.5 MPa. in the conventional acetic acid (HAc) system and the preparation of the ethyl chitosan material under the mass ratio of the two element ionic liquid system of 1- carboxymethyl -3- methyl imidazolium chloride ([Acmim]Cl) and glycine hydrochloride ([Gly]Cl). The preparation process of the membrane is optimized. The fracture of the ethyl chitosan membrane in the HAc system is broken. The tensile strength is 266.1 MPa, the elongation at break is 17%, the initial modulus is 2.3 GPa. two yuan ionic liquid system, the fracture strength of the ethyl chitosan film is 168.6MPa, the elongation at break is 11.4%, the initial modulus is 3.6 GPa., indicating that the fracture strength of the HAc system membrane is superior to the ionic liquid membrane, the ionic liquid system membrane and the HAc system membrane phase comparison table The surface is smooth, the contact angle is small, the swelling degree is small and the air permeability is poor. The blood compatibility of the two films prepared by the two kinds of membranes all have good blood compatibility. The reaction time is changed to prepare the butyl chitosan with different degree of substitution. The maximum substitution degree is 27.4% and the butyl chitosan membrane is obtained when the reaction time is 4 h. The fracture strength was 227.5 MPa. and the chitosan membrane was prepared under the HAc system and the two element ionic liquid system of [Acmim]Cl and [Gly]Cl. The preparation process of the membrane was optimized. The experimental results showed that the fracture strength of the butyl chitosan membrane was 291.2 MPa, the elongation at break was 12.5%, and the initial modulus was 1.9 GPa. ionic liquids. The fracture strength of the system membrane is 191.5 MPa, the elongation at break is 12.7% and the initial modulus is 3.4 GPa.. The results of the initial modulus of 3.4 GPa. show that the fracture strength of the HAc system membrane is superior to the ionic liquid system membrane. The ionic liquid system membrane has a relatively rough surface, the contact angle is small, the swelling degree is small, and the air permeability is poor. The biocompatibility of the two membranes prepared by the ionic liquid system is biocompatible. The two films have good biocompatibility. The reaction time is changed to prepare the octyl chitosan with different degrees of substitution. When the reaction time is 5 h, the maximum substitution degree is 23.9%. The fracture strength of the octyl chitosan film is the strongest 231.6 MPa., and the two element ionic liquid is mixed in the HAc system and the [Acmim] Cl and [Gly]Cl mass ratio. The octyl chitosan film was prepared under the body system to optimize the preparation process. The fracture strength of the octyl chitosan film in HAc system was 232 MPa, the elongation at break was 15.8%, the breaking strength of octyl chitosan film with initial modulus of 2 GPa. two yuan was 228.2 MPa, the elongation at break was 8.2%, and the initial modulus was 3.6 G. The results of Pa. show that the fracture strength of the HAc system membrane is better than that of the ionic liquid system membrane. The surface of the ionic liquid system membrane is relatively rough, the contact angle is small, the swelling degree is small, and the air permeability is poor. The blood compatibility of the two films prepared by the two kinds of membranes all have good blood compatibility. At the same time, the HAc system membrane is obtained. The mechanical properties of the butyl chitosan film are the strongest. The mechanical properties of the octyl chitosan film in the ionic liquid system membrane are the strongest. In general, the swelling degree of the HAc system membrane is higher than that of the ionic liquid membrane, and it is more easily degraded and absorbed as a medical material.
【學(xué)位授予單位】：青島科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O636.1

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