本文選題：嘧啶連三唑 + 席夫堿��； 參考：《江西師范大學(xué)》2017年碩士論文

【摘要】：嘧啶類(lèi)化合物、三唑類(lèi)衍生物的生物活性比較顯著,除了用于農(nóng)業(yè)方面的殺蟲(chóng)、殺菌和除草外,在醫(yī)藥中也用于抗腫瘤、消炎等方面,因而嘧啶類(lèi)化合物和三唑類(lèi)衍生物成為農(nóng)業(yè)醫(yī)藥等領(lǐng)域的研究熱點(diǎn)。依據(jù)生物活性亞結(jié)構(gòu)拼接原理,本文設(shè)計(jì)合成了78種新型的2-烷硫基-4-取代亞氨基-6-甲硫基-5-[5-(3-取代苯氧甲基-1H-1,2,4-三唑)]-嘧啶衍生物。所有的目標(biāo)化合物都經(jīng)核磁共振氫譜、碳譜、紅外光譜和質(zhì)譜等分析測(cè)試手段進(jìn)行了表征。所研究的內(nèi)容如下:Ⅰ:2-烷硫基-4-取代苯基亞氨基-6-甲硫基-5-[5-(3-取代苯氧甲基-1H-1,2,4-三唑)]-嘧啶衍生物(52個(gè))Ⅱ:2-烷硫基-4-苯乙烯基亞氨基-6-甲硫基-5-[5-(3-取代苯氧甲基-1H-1,2,4-三唑)]-嘧啶衍生物(9個(gè))Ⅲ:2-烷硫基-4-雜環(huán)亞氨基-6-甲硫基-5-[5-(3-取代苯氧甲基-1H-1,2,4-三唑)]-嘧啶衍生物(17個(gè))對(duì)所合成的目標(biāo)化合物進(jìn)行了初步的除草活性測(cè)試。測(cè)試結(jié)果表明大多數(shù)目標(biāo)化合物表現(xiàn)出優(yōu)異的除草活性,并對(duì)這些化合物的構(gòu)效關(guān)系進(jìn)行了研究。
[Abstract]:The biological activities of pyrimidine compounds and triazole derivatives are quite remarkable. In addition to their use in agriculture, insecticidal, bactericidal and herbicide, they are also used in medicine for anti-tumor and anti-inflammatory aspects. Therefore, pyrimidine compounds and triazole derivatives have become the research hotspot in agricultural medicine and other fields. According to the principle of bioactive substructure splicing, 78 new derivatives of 2-alkylthio-4- substituted imino -6-methylthio -5- [5-oxomethoxomethyl -1H-1H _ 1H-1H _ 1H ~ (2 +) -triazole] pyrimidine were designed and synthesized in this paper. All the target compounds were characterized by nuclear magnetic resonance (NMR), carbon spectroscopy, infrared spectroscopy and mass spectrometry. The contents of the study are as follows: I: 1: 2-alkylthio-4- substituted phenylimino-6-methylthio-5- [5-oxomethyl -1H-1- (2-triazole)] -pyrimidine derivatives (52) 鈪，

本文編號(hào)：1928383