本文選題：新型介質(zhì)阻擋放電離子源 + 合成藥物�。� 參考：《分析化學(xué)》2017年10期

【摘要】：本研究將單電極放電技術(shù)的DBDI與質(zhì)譜(MS)聯(lián)用,快速檢測(cè)了4種低極性的合成藥物,結(jié)果表明,4種合成藥物主要生成[M+H]~+分子離子。此外還利用DBDI-MS對(duì)草烏、制草烏切片進(jìn)行快速分析,在草烏中檢測(cè)到烏頭堿、中烏頭堿、脫氧烏頭堿的[M+H]~+離子,以及[M+H-60]~+碎片離子;在制草烏中只檢測(cè)到烏頭堿、中烏頭堿、脫氧烏頭堿的[M+H-60]~+碎片離子。所測(cè)草烏中的標(biāo)志性藥效成分主要為雙酯類生物堿,制草烏中的標(biāo)志性藥效成分主要為單酯類生物堿。新型DBDI為藥物研究提供了一種新的、快速檢測(cè)方法,具有十分重要的理論和實(shí)際應(yīng)用意義,在藥物研究領(lǐng)域具有極大的應(yīng)用潛力。
[Abstract]:In this study, 4 kinds of low polarity synthetic drugs were detected by DBDI and mass spectrometry (MS) of single electrode discharge technology. The results showed that the 4 kinds of synthetic drugs were mainly produced by [M+H]~+ molecular ions. In addition, DBDI-MS was used to make rapid analysis of the sliced kwood, and the [M+H]~ of aconitine, aconitine, and deoxy aconitine was detected in Kwu. + ions, and [M+H-60]~+ fragment ions; the [M+H-60]~+ fragments of aconitine, aconitine and deoxy aconitine were detected only in kwood. The main effective component of the test was double ester alkaloid, and the main effective component in the preparation was monoester alkaloid. A new type of DBDI provided a kind of drug research. The new rapid detection method is of great theoretical and practical significance and has great potential in the field of drug research.

【作者單位】： 寧波大學(xué)高等技術(shù)研究院;
【基金】：國(guó)家重大科學(xué)儀器設(shè)備開發(fā)專項(xiàng)項(xiàng)目(No.2016YFF0100300) 國(guó)家自然科學(xué)基金資助項(xiàng)目(No.51605231) 寧波大學(xué)王寬誠(chéng)幸福基金項(xiàng)目資助~~
【分類號(hào)】：O657;TQ460.72

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本文編號(hào)：1887831