本文選題：米諾地爾 + 毛細管區(qū)帶電泳��； 參考：《環(huán)境與健康雜志》2017年08期

【摘要】：目的建立化妝品中米諾地爾的毛細管區(qū)帶電泳(CZE)測定法。方法樣品經提取液(甲醇∶2 mmol/L磷酸二氫鈉+3 mmol/L磷酸體積比為1∶9)提取后離心,過0.45μm膜后上機。采用未涂敷熔融石英毛細管[75μm×30.2 cm(有效長度:20 cm)];分離緩沖液為20 mmol/L磷酸二氫鈉-30 mmol/L磷酸,pH 2.13;分離電壓為11 kV;檢測波長為278 nm;進樣壓力為0.5 psi;進樣時間為3 s。結果在1~160 mg/L的線性范圍內,所得米諾地爾的回歸方程為y=151.12x+73.363,r=0.999 95,呈良好的線性關系。該方法的檢出限為0.3 mg/L,定量下限為1.0 mg/L,平均回收率在93.4%~95.9%之間,RSD在3.3%~3.7%之間。結論該方法簡單、快速、準確,可用于化妝品中米諾地爾含量的檢測。
[Abstract]:Objective to establish a capillary zone electrophoresis (CZE) method for the determination of minoxidil in cosmetics. Methods the sample was extracted from the extract solution (methanol: 2 mmol/L sodium dihydrogen phosphate 3 mmol/L phosphoric acid volume ratio 1: 9) and centrifuged. The uncoated fused quartz capillary [75 渭 m 脳 30.2 cm (effective length: 20 cm)] was used, the separation buffer was 20 mmol/L sodium dihydrogen phosphate -30 mmol/L phosphate pH 2.13, the separation voltage was 11 KV, the detection wavelength was 278nm, the injection pressure was 0.5 psii and the injection time was 3 s. Results within the linear range of 1: 160 mg/L, the regression equation of minodil was YJ 151.12x 73.363C 0.999 95, showing a good linear relationship. The detection limit of this method is 0.3 mg / L, the limit of quantification is 1.0 mg / L, and the average recovery is between 93.44% and 95.9% (RSD = 3.3%). Conclusion the method is simple, rapid and accurate, and can be used for the determination of minoxidil in cosmetics.
【作者單位】： 北京市疾病預防控制中心中心實驗室食物中毒診斷溯源技術北京市重點實驗室;北京市預防醫(yī)學研究中心;北京化工大學理學院;首都醫(yī)科大學公共衛(wèi)生學院;
【基金】：北京市衛(wèi)生系統(tǒng)高層次衛(wèi)生技術人才培養(yǎng)項目(2013-2-036)
【分類號】：O658.9;TQ658

【相似文獻】

相關期刊論文 前2條

1 潘莉;郭新東;羅海英;冼燕萍;柯振華;陳意光;吳玉鑾;;高效液相色譜法測定洗發(fā)護發(fā)類化妝品中米諾地爾[J];江南大學學報(自然科學版);2011年02期

2 龔越強;呂冠欣;;HPLC測定中草藥育發(fā)類化妝品中非法添加的米諾地爾[J];食品與藥品;2014年04期

相關碩士學位論文 前1條

1 劉齊;高效液相色譜—質譜聯(lián)用法同時測定育發(fā)液中9種禁限用物質的研究[D];北京中醫(yī)藥大學;2017年

，

本文編號：1884492