本文選題：過渡金屬配合物　切入點：含氮羧酸配體　出處：《沈陽化工大學》2017年碩士論文

【摘要】：基于晶體工程的金屬超分子結(jié)構(gòu)設計和構(gòu)造目前在超分子化學和材料科學領域中引起了廣泛的興趣。不僅因為他們獨特的結(jié)構(gòu),還有他們的潛在應用,例如發(fā)光,催化和生物學應用等,尤其是在現(xiàn)代藥物學方面。在合理設計和控制合成這些功能化合物方面,多齒配體如多羧酸類和N-雜環(huán)配體得到了廣泛的應用。近期,N-雜環(huán)羧酸類配體在合成中應用十分廣泛,這是由于他們極其豐富的配位模式和功能特性,還有在溶液條件下作為氫鍵的給予體和受體的特點。過渡金屬配合物因其多樣的應用,如序列特異性結(jié)合,結(jié)構(gòu)探針和治療藥劑,在核酸化學中起到了重要作用。在過去的幾十年中,越來越多的含有過渡金屬離子如鉑和釕的配合物表現(xiàn)出來了有效的抗癌活性。但這些藥物具有嚴重的缺點,對生物靶標的選擇性差且具有高毒性。為了找到更好的非鉑基金屬配合物,我們合成了具有生物抗癌活性的配合物。1,4-雙(吡唑-1-基)對苯二甲酸是一種含有多個配位點的新型含氮羧酸配體,因而我們采用它合成了兩種新型過渡金屬配合物并進行了表征。本文研究的具體內(nèi)容主要包括以下方面:1、通過水熱方法分別制備了銅(Ⅱ)、錳(Ⅱ)配合物的單晶并采用X-射線單晶衍射對配合物進行了結(jié)構(gòu)的測定,并通過紅外光譜、元素分析進行了表征。2、采用紫外光譜法和熒光光譜法探究了銅(Ⅱ)、錳(Ⅱ)配合物同DNA的作用方式。通過瓊脂糖凝膠電泳測定了配合物對pBR322 DNA具有一定的切割能力。3、采用倒置熒光顯微鏡觀察了銅(Ⅱ)、錳(Ⅱ)配合物對HeLa細胞的作用效果,采用流式細胞儀測定了銅(Ⅱ)、錳(Ⅱ)配合物對KB細胞的殺傷能力。4、采用分子對接軟件YASARA進行了銅(Ⅱ)、錳(Ⅱ)配合物與蛋白質(zhì)的模擬對接,觀察了其結(jié)合模式。
[Abstract]:The design and construction of metallic supramolecular structures based on crystal engineering have attracted extensive interest in the field of supramolecular chemistry and material science.Not only because of their unique structure, but also because of their potential applications, such as luminescence, catalysis and biological applications, especially in modern pharmacology.Polydentate ligands such as polycarboxylic acids and N-heterocyclic ligands have been widely used in the design and control of these functional compounds.Recently, N-heterocyclic carboxylic acid ligands have been widely used in the synthesis because of their rich coordination patterns and functional characteristics, as well as the characteristics of donors and receptors as hydrogen bonds in solution.Transition metal complexes play an important role in nucleic acid chemistry because of their various applications, such as sequence specific binding, structural probes and therapeutic agents.In the past few decades, more and more complexes containing transition metal ions such as platinum and ruthenium have shown effective anticancer activity.However, these drugs have serious disadvantages, poor selectivity to biological targets and high toxicity.In order to find a better non-platinum metal complex, we synthesized a new nitrocarboxylic acid ligand with biological anticancer activity, I. e., 1,4-bis (pyrazolyl) terephthalic acid.Therefore, two new transition metal complexes were synthesized and characterized.The main contents of this paper are as follows: 1. The single crystals of copper (鈪，

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