本文選題：光聲圖像　切入點(diǎn)：單波長(zhǎng)　出處：《光譜學(xué)與光譜分析》2017年08期

【摘要】：血氧飽和度(SO_2)為臨床觀察病情變化提供了有意義的指標(biāo)。傳統(tǒng)血氧飽和度檢測(cè)研究工作多采用雙光源和多光源光電容積脈搏波描記法實(shí)現(xiàn)無創(chuàng)檢測(cè)來減少病人痛苦。通過研究生物組織對(duì)光的吸收和散射特性,將光譜學(xué)和光聲技術(shù)相結(jié)合提出了一種無創(chuàng)式單光源檢測(cè)血氧飽和度(SO_2)、脫氧血紅蛋白濃度[HBR]和氧合血紅蛋白濃度[HbO_2]的新方法。該方法基于血液對(duì)光信號(hào)的吸收和散射理論基礎(chǔ)和光聲信號(hào)呈現(xiàn)吸收線形關(guān)系建立單波長(zhǎng)光聲光譜血氧飽和度檢測(cè)技術(shù),不僅可以進(jìn)行指標(biāo)性參數(shù)分析還可以對(duì)組織成像。為了驗(yàn)證該技術(shù)可行性,在實(shí)驗(yàn)中采用單波長(zhǎng)激光脈沖光源,以綠色和紅色墨水的混合液體作為含有脫氧血紅蛋白和氧合血紅蛋白的血液模型注入軟管模擬人體血液環(huán)境。其中紅色墨水的含量類比于血液中含氧血紅蛋白含量,從而可通過測(cè)量計(jì)算出紅色和綠色墨水濃度來表征偽血氧飽和度(poseudo-SO_2)。實(shí)驗(yàn)結(jié)果表明,所測(cè)的偽血氧飽和度與實(shí)際濃度誤差不超過6.97%,采用該方法量化血氧飽和度是可行的;同時(shí)利用實(shí)驗(yàn)結(jié)果,結(jié)合光聲成像技術(shù)完成了對(duì)偽血液中單圓管截面成像。該方法替代多波長(zhǎng)光譜分析的方法能顯著降低激光系統(tǒng)和便攜式實(shí)現(xiàn)成本。
[Abstract]:Blood oxygen saturation (so _ 2) provides a significant index for clinical observation of the state of illness.In order to reduce the pain of patients, the traditional research work of oxygen saturation measurement mostly uses double light source and multiple light source photoelectric volumetric pulse wave method to realize noninvasive detection.By studying the light absorption and scattering characteristics of biological tissues, a new method for the detection of blood oxygen saturation, deoxyhemoglobin concentration (HBR) and oxygenated hemoglobin concentration (HbO_2) by combining spectroscopy with photoacoustic technique is proposed.Based on the theory of blood absorption and scattering and the absorption linear relationship of the photoacoustic signal, a single wavelength photoacoustic spectral oxygen saturation detection technique is established, which can not only be used for parameter analysis, but also for tissue imaging.In order to verify the feasibility of this technique, a single wavelength laser pulse light source was used in the experiment. The mixture of green and red ink was used as a blood model containing deoxyhemoglobin and oxygenated hemoglobin to simulate the human blood environment.The content of red ink is analogous to the content of oxygenated hemoglobin in blood, so the pseudo oxygen saturation can be expressed by measuring and calculating the concentration of red ink and green ink.The experimental results show that the error between the measured pseudo oxygen saturation and the actual concentration is less than 6.97, and it is feasible to quantify the oxygen saturation by using this method, and at the same time, using the experimental results and the photoacoustic imaging technique, we have completed the imaging of the cross section of the single tube in the pseudo blood.This method can significantly reduce the cost of laser system and portable implementation instead of multiwavelength spectral analysis.
【作者單位】： 四川大學(xué)物理科學(xué)與技術(shù)學(xué)院;
【基金】：Project Supported by National Natural Science Foundation of China(81370350) Project Supported by Sichuan Provincial Department of Science and Technology(2012JY0089)
【分類號(hào)】：O657.3;R44

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