本文選題：水凝膠　切入點(diǎn)：雙網(wǎng)絡(luò)　出處：《長春工業(yè)大學(xué)》2017年碩士論文

【摘要】：水凝膠是一種具有三維網(wǎng)絡(luò)結(jié)構(gòu)的高分子材料,具有良好的親水性和生物相容性,在藥物釋放、組織工程、人工軟骨材料、刺激響應(yīng)性材料等領(lǐng)域具有良好的應(yīng)用前景。本文中,我們采用不同的原料和方法制備了兩種具有特殊性能的水凝膠,主要研究?jī)?nèi)容和結(jié)論概括如下:(1)采用兩步法制備了pH響應(yīng)的高強(qiáng)度雙網(wǎng)絡(luò)水凝膠,凝膠由硼酸鹽交聯(lián)的羥丙基胍膠網(wǎng)絡(luò)(HPG)和共價(jià)交聯(lián)的聚丙烯酰胺網(wǎng)絡(luò)(PAAm)組成�；陔p網(wǎng)絡(luò)水凝膠的能量耗散機(jī)制,利用硼酸根(B(OH)4-)能與HPG上的順式羥基交聯(lián)的特性,以硼酸鹽交聯(lián)的HPG網(wǎng)絡(luò)作為第一網(wǎng)絡(luò),PAAm作為第二網(wǎng)絡(luò),制備的DN水凝膠具有優(yōu)良的機(jī)械性能,斷裂強(qiáng)度可以達(dá)到843 kPa,斷裂伸長率達(dá)到1400%。此外,在不同的pH條件下,硼酸鹽水解產(chǎn)生的B(OH)4-濃度不同,使HPG網(wǎng)絡(luò)的交聯(lián)密度發(fā)生變化,凝膠顯示出獨(dú)特的pH響應(yīng)性。相較于其他已經(jīng)制備的響應(yīng)性凝膠,HPG/PAAm凝膠以雙網(wǎng)絡(luò)理論為基礎(chǔ),通過HPG網(wǎng)絡(luò)的引入,在具有優(yōu)異的機(jī)械性能的同時(shí)實(shí)現(xiàn)了pH響應(yīng)性。(2)前期工作制備的HPG/PAAm凝膠具有優(yōu)異的機(jī)械強(qiáng)度和pH響應(yīng)性,但由于硼酸根與順式羥基交聯(lián)的弱可逆性以及PAAm鏈的化學(xué)交聯(lián),凝膠只是在小形變過程中顯示弱的可恢復(fù)性,并不具備宏觀的可愈合性。因此,我們?cè)诘诙䝼�(gè)實(shí)驗(yàn)體系中作出了新的探索,制備出新型的羥丙基胍膠/N,N-二甲基丙烯酰胺(HPG/PDMA)凝膠,顯示高效快速的愈合性能。HPG網(wǎng)絡(luò)通過鏈上的羥基之間的氫鍵形成,PDMA網(wǎng)絡(luò)在沒有化學(xué)交聯(lián)劑的情況下自交聯(lián)形成,與此同時(shí),HPG網(wǎng)絡(luò)與PDMA網(wǎng)絡(luò)之間還存在物理交聯(lián)作用�；诩{米吸附作用,使用納米二氧化硅作為可逆交聯(lián)點(diǎn),凝膠在室溫下可以完全愈合,在2 h時(shí)愈合率可以達(dá)到102%。
[Abstract]:Hydrogel is a kind of polymer material with three-dimensional network structure, which has good hydrophilicity and biocompatibility. It has a good application prospect in the fields of drug release, tissue engineering, artificial cartilage materials, stimulative responsive materials and so on.In this paper, two kinds of hydrogels with special properties were prepared by different raw materials and methods. The main contents and conclusions were summarized as follows: 1) Two-step method was used to prepare high-strength double-network hydrogels with pH response.The gel consists of hydroxypropyl guanidine gel (HPGs) crosslinked by borate and PAA (a covalent crosslinked polyacrylamide network).Based on the energy dissipation mechanism of double network hydrogels, the properties of borate BOH4) can be cross-linked with cis-hydroxyl groups on HPG. The borate crosslinked HPG network is used as the first network and PAAm as the second network.The prepared DN hydrogel has excellent mechanical properties, the fracture strength can reach 843 KPA, and the elongation at break reaches 1 400.In addition, under different pH conditions, the concentration of BnOH4- produced by the hydrolysis of borate salt water changed the crosslinking density of HPG network, and the gel showed a unique pH response.Compared with other responsive gels that have been prepared, HPG / PAAm gel is based on the theory of double networks and is introduced into HPG networks.At the same time, the HPG/PAAm gel prepared by the previous work of pH responsivity has excellent mechanical strength and pH response, but due to the weak reversibility of borate and cis-hydroxyl group crosslinking and the chemical crosslinking of PAAm chain.Gel only shows weak recoverability in the process of small deformation and does not have macroscopical healing ability.Therefore, we made a new exploration in the second experimental system, we prepared a new type of hydroxypropyl guanidine gel / N-dimethylacrylamide HPG-PDMA-gel.It is shown that the highly efficient and rapid healing properties of the HPG network are formed by hydrogen bonds between the hydroxyl groups in the chain, and the self-crosslinking is formed without the chemical crosslinking agent. At the same time, there is physical crosslinking between the HPG network and the PDMA network.Based on the adsorption of nano-silica, the gel can heal completely at room temperature with nano-silica as the reversible crosslinking point, and the healing rate can reach 102% at 2 h.
【學(xué)位授予單位】：長春工業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O648.17

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 劉壯;謝銳;巨曉潔;汪偉;褚良銀;;環(huán)境刺激響應(yīng)型高強(qiáng)度智能水凝膠研究進(jìn)展[J];化工進(jìn)展;2016年06期

2 劉壯;謝銳;巨曉潔;汪偉;褚良銀;;具有快速響應(yīng)特性的環(huán)境響應(yīng)型智能水凝膠的研究進(jìn)展[J];化工學(xué)報(bào);2016年01期

3 陳詠梅;董坤;劉振齊;徐峰;;高強(qiáng)度雙網(wǎng)絡(luò)高分子水凝膠:性能、進(jìn)展及展望[J];中國科學(xué):技術(shù)科學(xué);2012年08期

4 董坤;魏釗;楊志懋;陳詠梅;;自愈合凝膠:結(jié)構(gòu)、性能及展望[J];中國科學(xué):化學(xué);2012年06期

5 王雪珍;汪輝亮;;具有規(guī)整結(jié)構(gòu)和高強(qiáng)度的水凝膠研究進(jìn)展[J];高分子通報(bào);2008年03期

，

本文編號(hào)：1705814