本文選題：去對(duì)稱化　切入點(diǎn)：生物轉(zhuǎn)化　出處：《有機(jī)化學(xué)》2016年10期

【摘要】：腈的化學(xué)水合和水解具有反應(yīng)條件苛刻、低選擇性等缺點(diǎn),與之相反,腈的去對(duì)稱化生物轉(zhuǎn)化反應(yīng)具有反應(yīng)條件溫和、高效、高選擇性以及理論產(chǎn)率可達(dá)100%的優(yōu)點(diǎn),已成為合成對(duì)映體純多官能化羧酸和酰胺的最有效方法之一.將分別從前手性戊二腈、前手性丙二腈、內(nèi)消旋環(huán)狀二腈以及其他類底物出發(fā),簡(jiǎn)單綜述腈類化合物的去對(duì)稱化生物轉(zhuǎn)化反應(yīng)及其在有機(jī)合成中的應(yīng)用進(jìn)展,并對(duì)各類反應(yīng)的條件、選擇性以及規(guī)律機(jī)制進(jìn)行討論和總結(jié).
[Abstract]:The chemical hydration and hydrolysis of nitrile have the disadvantages of harsh reaction conditions and low selectivity. On the contrary, the reaction conditions are mild, high efficiency, high selectivity and theoretical yield of 100%. It has become one of the most effective methods for the synthesis of enantiomer pure multifunctional carboxylic acids and amides. Starting from the prochiral glutaronitrile, the prochiral malonitrile, the racemic cyclic dinitrile and other substrates, This paper briefly reviews the desymmetric bioconversion reaction of nitriles and its application in organic synthesis, and discusses and summarizes the conditions, selectivity and regular mechanism of various reactions.
【作者單位】： 中國(guó)科學(xué)院化學(xué)研究所北京分子科學(xué)國(guó)家實(shí)驗(yàn)室中國(guó)科學(xué)院分子識(shí)別與功能重點(diǎn)實(shí)驗(yàn)室;中國(guó)科學(xué)院大學(xué);
【基金】：國(guó)家自然科學(xué)基金(No.21502202)資助項(xiàng)目~~
【分類號(hào)】：O621.25

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 徐美珍;任杰;龔勁松;董文s，

本文編號(hào)：1691347