本文選題：碳量子點(diǎn)　切入點(diǎn)：三聚氰胺　出處：《遼寧大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：近年來,碳量子點(diǎn)(又名碳點(diǎn)、碳納米點(diǎn)、C-dots、CDs)因?yàn)槠鋬?yōu)異的熒光特性而受到了大家的廣泛關(guān)注。由于碳量子點(diǎn)還具有尺寸小、分布窄、毒性低和生物相容性好等特點(diǎn),被廣泛應(yīng)用于各種生物成像、生物傳感、藥物裝載與運(yùn)輸以及疾病治療等方面。本文就是利用了碳量子點(diǎn)優(yōu)異的熒光特性和對(duì)一些物質(zhì)靈敏的響應(yīng)性,將其應(yīng)用于生物分析檢測(cè)、生物藥物的運(yùn)載等方面。主要工作內(nèi)容如下:一、選取一種廉價(jià)易得的原料三聚氰酸,通過水熱法合成了一種熒光性能良好的三聚氰酸碳點(diǎn),并借助三聚氰胺和三聚氰酸之間強(qiáng)烈的三重氫鍵作用,通過三聚氰胺分子對(duì)碳量子點(diǎn)的熒光強(qiáng)度的影響來實(shí)現(xiàn)對(duì)三聚氰胺濃度的定量檢測(cè)。二、以尿素和乙二胺為原料通過微波法合成一種表面充滿氨基的碳量子點(diǎn)。又以聚天冬氨酸、聚乙二醇為原料,合成了一種含有一段離子嵌段的,由聚乙二醇(PEG)和聚天冬氨酸(PAsp)構(gòu)成的二嵌段共聚物。然后通過靜電作用自組裝方式形成一種以碳量子點(diǎn)為內(nèi)核,以二嵌段共聚物聚乙二醇聚天冬氨酸(PEG-b-PAsp)為外殼的具有良好熒光發(fā)射的熒光靜電膠束。將靜電膠束用于金屬離子的檢測(cè),測(cè)試結(jié)果表明形成靜電膠束后對(duì)金屬離子的檢測(cè)靈敏度明顯增強(qiáng)。接著對(duì)靜電膠束進(jìn)行了藥物運(yùn)載等方面的研究,并通過細(xì)胞毒性測(cè)試、細(xì)胞內(nèi)吞實(shí)驗(yàn)等證明了靜電膠束的無毒性、良好的生物相容性,能夠作為一種優(yōu)良的納米藥物載體。
[Abstract]:In recent years, carbon quantum dots (also known as carbon, carbon nanotubes, C-dots, CDs) because of its excellent fluorescence properties and by all the attention. Because the carbon quantum dot has the features of small size, narrow distribution, low toxicity and good biocompatibility, is widely used in a variety of biological imaging, biological sensing, drug loading and transportation as well as disease treatment. This article is the use of the fluorescence properties of carbon quantum dots and some excellent material sensitive response, its application in biological analysis and detection, such as carrying biological drugs. The main work contents are as follows: first, choose a cheap raw materials melamine cyanate, cyanuric acid carbon a good fluorescence properties were synthesized by hydrothermal method, and with the help of between melamine and cyanuric acid, three strong hydrogen bonding interactions, affect the fluorescence intensity by melamine molecules on carbon quantum dots to To realize the quantitative detection of melamine concentration. Two, urea and ethylenediamine as raw material by CQDS microwave synthesis of a surface with amino. With polyaspartic acid, polyethylene glycol as raw materials to synthesize a contains a ion block, by polyethylene glycol (PEG) and poly (aspartic acid PAsp) two block copolymer composition. Then through electrostatic self-assembly to form a carbon quantum dots as the core, with two polyethylene glycol copolymer of polyaspartic acid (PEG-b-PAsp) with fluorescence emission of good beam static rubber shell. The electrostatic detection of metal ions for micelles. The test results show that the formation of micelles after electrostatic detection sensitivity to metal ions significantly enhanced. Then study drug delivery and other aspects of the electrostatic micelles, and through cytotoxicity test, endocytosis experiments proved that electrostatic glue The nontoxic and good biocompatibility of the bundle can be used as a fine carrier for nanoscale drugs.

【學(xué)位授予單位】：遼寧大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O657.3

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